Air flow management for vaporizer device

专利摘要:
Air flow management for vaporizer device A vaporizer device includes a cartridge having a reservoir which contains vaporizable material, a heating element, and a capillary element which can draw the vaporizable material to the heating element for be sprayed. The capillary element may have two ends in contact with the reservoir. The cartridge may include an air flow control element for controlling the flow of air through the cartridge. Figure for the abstract: Fig. 1
公开号:FR3083983A1
申请号:FR1908354
申请日:2019-07-23
公开日:2020-01-24
发明作者:Ariel Atkins；Adam Bowen；Steven Christensen；Nicholas J. HATTON；Esteban Leon Duque；James Monsees；Christopher James Rosser；Andrew J. Stratton
申请人:Cambridge Consultants Ltd；Juul Labs Inc；
IPC主号:

专利说明:

Description
Title of the invention: Air flow management for vaporizer device
Technical Field [0001] The present invention relates to vaporizer devices, comprising portable vaporizer devices for generating an inhalable aerosol from one or more vaporizable materials.
Background The vaporizer devices, which may also be called vaporizers, electronic vaporizer devices or e-vaporizer devices, can be used for the administration of an aerosol (or "vapor") containing one or more active substances by inhalation of the aerosol by a user of the spray device. For example, electronic nicotine delivery systems (ENDS) include a class of vaporizer devices that are battery powered and can be used to simulate the experience of smoking, but without the burning of tobacco or other substances.
In the use of a vaporizer device, the user inhales an aerosol, commonly called vapor, which can be generated by a heating element that vaporizes (for example, by bringing a liquid or a solid to pass to the less partially in the gas phase) a vaporizable material, which can be a liquid, a solution, a solid, a wax, or any other form which can be compatible with the use of a specific vaporizing device. The vaporizable material used with a vaporizer may be disposed in a cartridge (for example, a separable portion of the vaporizer which contains the vaporizable material in a reservoir) which includes a mouthpiece (for example, for inhalation by a user).
To receive the inhalable aerosol generated by a vaporizer device, a user can, in some examples, activate the vaporizer device by taking a puff, at the press of a button, or by another approach. A puff, as the term is commonly used (and also used today), designates inhalation by the user in a way that causes a volume of air to be drawn into the vaporizer so that the aerosol inhalable is generated by a combination of vaporizable material vaporized with air.
A typical approach by which a vaporizer device generates an inhalable aerosol from a vaporizable material implements the heating of the vaporizable material in a vaporization chamber (or a heating device chamber) to bring the vaporizable material to be converted to the gas (or vapor) phase. A vaporization chamber generally refers to an area or volume in the vaporizer device in which a heat source (for example, conduction, convection, and / or radiant) causes heating of a vaporizable material to produce a mixture air and vaporizable material vaporized to form vapor for inhalation by a user of the vaporizer.
In some embodiments of the vaporizer device, the vaporizable material can be sucked out of a reservoir or a reservoir chamber and into the vaporization chamber via a capillary element (a wick ). Such aspiration of the vaporizable material in the vaporization chamber may be due, at least in part, to the capillary action produced by the wick, which attracts the vaporizable material along the wick in the direction of the vaporization chamber. However, when the vaporizable material is sucked out of the tank, the pressure inside the tank is reduced, thus creating a vacuum and acting against capillary action. This can reduce the efficiency of the wick for sucking the vaporizable material into the vaporization chamber, thereby reducing the efficiency of the vaporizing device to vaporize a desired amount of vaporizable material, for example when a user takes a puff on the device. of spray bottle. In addition, the vacuum created in the tank can ultimately lead to the inability to suck all of the vaporizable material into the vaporization chamber, thereby wasting vaporizable material. Therefore, improved spray devices and / or spray cartridges that improve or resolve these problems are desired.
The term vaporizer device, in the present context and in accordance with the present object, generally designates portable, autonomous devices which are practical for personal use. Typically, such devices are controlled by one or more switches, buttons, touch devices, or user input functionality or the like (which may be commonly referred to as controls) on the vaporizer, although different devices can communicate wirelessly. with an external control device (for example, a smartphone, a connected watch, other wearable electronic devices, etc.) have recently become available. A control, in this context, generally designates an ability to influence one or more of different operating parameters, which may include, without limitation, the action of causing the heating device to be activated and / or deactivated, the setting of a minimum and / or maximum temperature to which the heating device is heated during operation, various games or other interactive elements which a user can access on a device, and / or other operations.
Summary of the Invention In certain aspects of the present object, the difficulties associated with the presence of liquid vaporizable materials in or near certain sensitive components of an electronic vaporizer device can be resolved by the inclusion of a or several of the elements presently described or comparable / equivalent approaches as will be apparent to those skilled in the art. Aspects of the subject matter relate to methods and a system for managing the flow of air in a vaporizer device.
In one aspect, an embodiment of a cartridge for a vaporizer device is described. The cartridge may include a reservoir chamber defined by a reservoir barrier. The reservoir chamber can be configured to contain a liquid vaporizable material. The cartridge may further include a vaporization chamber in fluid communication with the reservoir chamber and include a capillary element configured to suck the liquid vaporizable material from the reservoir chamber to the vaporization chamber to be vaporized by a heating element. The cartridge may further include an air flow passage which extends through the vaporization chamber and an air flow control element for controlling reservoir pressure in the reservoir chamber.
In certain variants, one or more of the following elements can optionally be included in any workable combination. The air flow control element may include a fluid passage extending between the reservoir chamber and the air flow passage. The diameter of the fluid passage can be dimensioned to allow a surface tension of the liquid vaporizable material to prevent the passage of the liquid vaporizable material through the fluid passage when the reservoir pressure is approximately the same as a second pressure along the air flow passage. The diameter can be dimensioned to allow the surface tension of the liquid vaporizable material to be broken when the reservoir pressure is less than the second pressure along the air flow passage, allowing a volume of air to pass through the air flow control element and entering the tank chamber.
The air flow control element may include a non-return valve or a duckbill valve. The air flow control element may include a coating comprising a ventilation material extending over an opening of the fluid passage. The coating may include a polytetrafluoroethylene (PTLE) material. The air flow control element may include one or more of a septum, a valve, and a pump. The air flow control member may include an air passage extending along at least one side of a wick housing containing the vaporization chamber, and the air passage may be spread between the tank chamber and the vaporization chamber. The air flow control element may include an air passage extending through a wick housing containing the vaporization chamber, and the air passage may extend between the reservoir chamber and the vaporization chamber.
In some embodiments, the cartridge may further include a pressure sensor configured to detect pressure along the air flow passage. The cartridge may further include a secondary passage configured to draw air through a portion of the cartridge, and the secondary passage may be configured to merge with the air flow passage downstream of the vaporization chamber. The cartridge may further include a pressure sensing passage which extends between an outlet of the cartridge and a pressure sensor, the pressure sensing passage being separable from the air flow passage.
The cartridge may further include an inlet positioned along a first side of the cartridge and an outlet positioned along a second side of the cartridge. The air flow path can extend between the inlet and outlet, and the inlet and outlet can be positioned along the first side and the second side, respectively, so that the inlet and the outlets are open when the cartridge is inserted into a vaporizer body in a first position and are closed when the cartridge is inserted into the vaporizer body in a second position. The capillary element may include a flat configuration comprising at least a pair of opposite sides which extend parallel to each other.
In another related aspect of the present object, a method includes a step of allowing an air flow to pass through the vaporization chamber of a vaporizer device, thereby combining the air flow with an aerosol formed in the vaporization chamber. The aerosol can be formed by vaporizing a liquid vaporizable material aspirated from a porous wick extending between the vaporization chamber and a reservoir chamber containing the liquid vaporizable material. The method may further include a step of sucking liquid vaporizable material along the porous wick from the reservoir chamber to the vaporization chamber, thereby creating a first pressure in the reservoir chamber which is less than a second pressure in an area outside the tank chamber. In addition, the method may include a step of breaking a surface tension of the liquid vaporizable material along an aeration passage extending between the reservoir chamber and the area outside the reservoir chamber, allowing thus a volume of air to pass into the tank chamber from the ventilation passage. Additionally, the method may include a step of increasing the first pressure in the tank chamber so that the first pressure is approximately equal to the second pressure.
In some embodiments, the method may further include a step of preventing, as a result of the first pressure being approximately equal to the second pressure, the passage of fluid along the aeration passage. Prevention can be controlled by the fluid tension of the vaporizable fluid. The vaporizable fluid can include at least one of the liquid vaporizable material and air. The air flow control element may include an air passage extending through a wick housing which contains the vaporization chamber. The air flow control element may include a fluid passage extending between the reservoir chamber and an air flow passage.
The details of one or more variants of the object currently described are presented in the accompanying drawings and the description below. Other elements and advantages of the object presently described will become apparent on reading the description and the drawings, and the claims.
Brief Description of the Drawings The accompanying drawings, which are incorporated into and form part of this specification, present certain aspects of the object presently described and, together with the description, help explain some of the principles associated with the implementations. described. In the drawings:
[Fig.lA] Figure IA shows a first embodiment of a vaporizer system comprising a vaporizer device comprising a cartridge and a body of the vaporizer device consistent with implementations of the present object;
[Fig.lB] Figure IB illustrates a top view of an embodiment of the vaporizer device of Figure IA showing a cartridge separated from a body of the vaporizer device;
[Fig.lC] Figure IC illustrates a top view of the vaporizer device of Figure IB with the cartridge inserted into a cartridge receptacle of the body of the vaporizer device;
[Fig.lD] Figure 1D shows a perspective view of the vaporizer device of Figure IB;
[Fig.lE] Figure 1E shows a perspective view of the cartridge of the vaporizer device of Figure IB;
[Fig.lF] Figure 1F shows another perspective view of the cartridge of Figure IE;
[Fig.2A] Figure 2A illustrates a diagram of a first embodiment of a reservoir system configured for a vaporizer cartridge and / or a vaporizer device to improve the air flow in the vaporizer device;
[Fig.2B] Figure 2B illustrates a diagram of a second embodiment of a reservoir system configured for a vaporizer cartridge and / or a vaporizer device to improve the air flow in the vaporizer device;
[Fig.3A] Figure 3A shows a front view of an embodiment of a vaporization chamber ventilation element comprising a tubing vent coupled to a wick housing;
[Fig.3B] Figure 3B illustrates a front cross-sectional view of the vaporization chamber ventilation element of Figure 3A;
[Fig.4A] Figure 4A shows a front view of another embodiment of a vaporization chamber ventilation element comprising a channel extending through a wick housing;
[Fig.4B] Figure 4B illustrates a front cross-sectional view of the vaporization chamber ventilation element of Figure 4A;
[Fig.5A] Figure 5A shows a front view of another additional embodiment of a vaporization chamber ventilation element comprising a channel extending through a wick housing;
[Fig.5B] Figure 5B illustrates a front cross-sectional view of the vaporization chamber ventilation element of Figure 5A;
[Fig.6A] Figure 6A shows a perspective view from above of another embodiment of a vaporization chamber ventilation element comprising two ventilation passages which are each defined in part by a channel extending along a front side of a wick housing;
[Fig.6B] Figure 6B illustrates a partial view of the cartridge of Figure 6A showing the wick housing and the vents;
[Fig.7A] Figure 7A shows a perspective view from above of another embodiment of a vaporization chamber ventilation element comprising two ventilation passages which are each defined in part by a channel extending along one side of a wick housing;
[Fig.7B] Figure 7B illustrates a partial view of the cartridge of Figure 7A showing the wick housing and the vents;
[Fig.8A] Figure 8A shows a perspective view from above of another embodiment of a vaporization chamber ventilation element comprising an ventilation passage which is defined in part by a corner chamfered with a drill bit housing;
[Fig.8B] Figure 8B illustrates a partial view of the cartridge of Figure 8A re7 having the wick housing and the vent;
[Fig.9A] Figure 9A shows a perspective view from above of another embodiment of a vaporization chamber ventilation element comprising two ventilation passages which are each defined in part by a chamfered corner of a wick housing;
[Fig.9B] Figure 9B illustrates a partial view of the cartridge of Figure 9A showing the wick housing and the vents;
[Fig.10] Figure 10 shows another embodiment of a vaporization chamber ventilation element comprising at least one molded vent assembled with and extending parallel to the air flow passage;
[Fig.l 1] Figure 11 shows another embodiment of a vaporization chamber ventilation element comprising at least one molded vent assembled and extending parallel to a wick passage;
[Fig.l2A] Figure 12A shows a schematic diagram illustrating elements of a vaporizer cartridge having a flattened wick;
[Fig. 12B] Figure 12B illustrates a perspective view from above of the flattened lock of Figure 12A;
[Fig.l3A] Figure 13A illustrates another embodiment of a vaporizer cartridge consistent with implementations of this object;
[Fig. 13B] Figure 13B illustrates a partial front view of the vaporizer cartridge of Figure 13A;
[Fig.l4A] Figure 14A illustrates another embodiment of a vaporizer cartridge being inserted in another embodiment of a vaporizer device body comprising a pressure sensor;
[Fig. 14B] Figure 14B illustrates a front view of the vaporizer cartridge inserted into the vaporizer device body of Figure 14A;
[Fig.l4C] Figure 14C illustrates a schematic example of the pressure sensor in the body of the vaporizer device of Figure 14A positioned at different locations along an air path;
[Fig.l4D] Figure 14D illustrates an example of coupling of the vaporizer cartridge and the body of the vaporizer device of Figure 14A; and [fig. 50 14E] Figure 14E illustrates an example of the cooling air flow path of the vaporizer cartridge and the vaporizer device body of Figure 14A.
As far as possible, similar reference numbers designate similar structures, characteristics or elements.
Detailed Description The implementations of this object include devices associated with the spraying of one or more materials for inhalation by a user. The term "vaporizer" is used generically in the following description to designate a vaporizer device. Examples of vaporizers consistent with implementations of the subject matter include electronic vaporizers, or the like. Such vaporizers are generally portable, portable devices which heat a vaporizable material to provide an inhalable dose of the material.
The vaporizable material used with a vaporizer can optionally be supplied in a cartridge (for example, a portion of the vaporizer which contains the vaporizable material in a reservoir or other container and which can be refillable when empty or disposable for be replaced with a new cartridge containing additional vaporizable material of the same or different type). A vaporizer can be a vaporizer using a cartridge, a vaporizer without a cartridge, or a multi-use vaporizer that can be used with or without a cartridge. For example, a multi-use vaporizer may include a heating chamber (e.g., an oven) configured to receive vaporizable material directly into the heating chamber and also to receive a cartridge or other replaceable device having a reservoir, a volume , or the like to at least partially contain a usable amount of vaporizable material.
In different implementations, a vaporizer can be configured for use with a liquid vaporizable material (for example, a vehicle solution in which one or more active and / or inactive component (s) are put suspended or maintained in solution or a pure liquid form of the vaporizable material itself) or a solid vaporizable material. A solid vaporizable material can include a plant material which emits part of the plant material as vaporizable material (for example, so that part of the plant material remains as waste after the vaporizable material has been emitted for inhalation by a user) or may optionally be a solid form of the vaporizable material itself (eg, a "wax") such that all of the solid material can ultimately be vaporized for inhalation. A liquid vaporizable material may similarly be able to be completely vaporized or may comprise part of the liquid material which remains after all of the material suitable for inhalation has been consumed.
Figures IA to 1F illustrate an example of a vaporizer 100 comprising a vaporizer body 110 and a vaporizer cartridge 120, any of which may include elements therein consistent with implementations of this object. Referring to the block diagram of Figure IA, a vaporizer 100 typically includes a power source 112 (such as a battery, which may be a rechargeable battery), and a control device 104 (for example, a processor, circuits, etc., capable of executing logic) to control the distribution of heat to an atomizer 141 to cause vaporizable material to be converted to a condensed form (e.g., solid, liquid, solution, suspension , part of an at least partially untreated plant material, etc.) to the gas phase. The control device 104 may be part of one or more printed circuit boards (PCB) consistent with certain implementations of the present object.
After the conversion of the vaporizable material into the gas phase, and depending on the type of vaporizer, the physical and chemical properties of the vaporizable material, and / or other factors, at least part of the vaporizable material in the gas phase can condense to form particulate matter in at least a partial local equilibrium with the gas phase as part of an aerosol, which may form part or all of an inhalable dose supplied by the vaporizer 100 for a given puff or suction on the vaporizer. It will appear that the interaction between the gas and condensed phases in an aerosol generated by a vaporizer can be complex and dynamic, since factors such as ambient temperature, relative humidity, chemistry, flow conditions in air flow paths (both inside the vaporizer and in the respiratory tract of a human or other animal), mixing the vaporizable material in the gas phase or aerosol phase with other air flow, etc., can affect one or more physical parameters of an aerosol. In some vaporizers, and particularly for vaporizers for administration of more volatile vaporizable materials, the inhalable dose may exist predominantly in the gas phase (i.e., the formation of condensed phase particles may be very limited) .
Vaporizers for use with liquid vaporizable materials (for example, pure liquids, suspensions, solutions, mixtures, etc.) typically include an atomizer 141 in which a capillary element (also referred to herein as a wick ( not shown in Figure IA), which may include any material capable of causing fluid movement by capillary pressure) conveys an amount of a vaporizable liquid material to a part of the atomizer which includes a heating element (also not shown in Figure IA). The capillary element is generally configured to aspirate liquid vaporizable material from a reservoir configured to contain (and which may, in use, contain) the liquid vaporizable material so that the liquid vaporizable material can be vaporized by the heat delivered by a heating element. The capillary element can also optionally allow air to enter the reservoir to replace the volume of liquid removed. In other words, the capillary action attracts the liquid vaporizable material in the wick for vaporization by the heating element (described below), and the air can, in certain implementations of the present object, return to the reservoir via the wick to at least partially equalize the pressure in the reservoir. Other approaches to allow the return of air to the tank to equalize the pressure are also within the scope of this object.
The heating element may be or include one or more of a conduction heating device, a radiant heating device, and a convection heating device. One type of heating element is a resistive heating element, which may be made of, or at least comprise, a material (eg, a metal or an alloy, eg a nickel-chromium alloy, or a non-metallic resistance ) configured to dissipate electrical power in the form of heat when an electrical current flows through one or more resistive segments of the heating element. In some implementations of the present object, an atomizer may include a heating element which includes a resistive coil or other heating element wound around it, positioned in, integrated in a mass form of, pressed in thermal contact with, or otherwise arranged to deliver heat to, a capillary element to cause a liquid vaporizable material aspirated by the capillary element from a reservoir to be vaporized for subsequent inhalation by a user in a gaseous and / or condensed phase (by for example, aerosol particles or droplets). Other configurations of capillary element, heating element and / or atomizer assembly are also possible, as described further below.
Certain vaporizers can also, or as a variant, be configured to create an inhalable dose of vaporizable material in the gas phase and / or in the aerosol phase by heating a non-liquid vaporizable material, such as, for example, a solid phase vaporizable material (for example, a wax or the like) or a plant material (for example, tobacco leaves and / or parts of tobacco leaves) containing the vaporizable material. In such vaporizers, a resistive heating element may be part of, or otherwise be incorporated into, or in thermal contact with the walls of an oven or other heating chamber in which the non-liquid vaporizable material is placed. Alternatively, a resistive heating element or elements may be used to heat the air passing through or past the non-liquid vaporizable material to cause convective heating of the non-liquid vaporizable material. In other additional examples, a resistive heating element or elements may be arranged in intimate contact with a plant material so that heating by direct conduction of the plant material occurs in a mass of the plant material (e.g., as opposed to only by conduction heating inwards from the walls of an oven).
The heating element can be activated (for example, a control device, which is optionally part of a vaporizer body as described below, can cause current to flow from the power source through a circuit comprising the resistive heating element, which is optionally part of a vaporizer cartridge as described below), in association with a user taking (e.g., aspirating, inhaling, etc.) a puff on a mouthpiece 130 of the vaporizer to cause the air to flow from an air inlet, along an air flow path which passes through an atomizer (for example, a capillary element and a heating element), optionally through one or more condensation zones or chambers, up to an air outlet in the mouthpiece. The incoming air passing along the air flow path passes over, through, etc., the atomizer, where the vaporizable material in the gas phase is entrained in the air. As noted above, entrained vapor phase material can condense as it passes through the rest of the air flow path so that an inhalable dose of the vaporizable material in aerosol form can be dispensed from the outlet air (for example, into a mouthpiece 130 for inhalation by a user).
The activation of the heating element can be caused by automatic detection of the puff on the basis of one or more of signals generated by one or more sensors 113, such as, for example, a sensor or pressure sensors arranged to sense the pressure along the air flow path relative to ambient pressure (or optionally to measure changes in absolute pressure), one or more vaporizer movement sensors, one or more several vaporizer flow sensors, a capacitive vaporizer lip sensor; in response to detection of user interaction with one or more input devices 116 (for example, buttons or other tactile control devices of the vaporizer 100), receiving signals from a computer device in communication with the vaporizer; and / or other approaches to determine that a puff occurs or is imminent.
As mentioned in the previous paragraph, a vaporizer consistent with implementations of the present object can be configured for connection (for example, wireless or via a wired connection) to a computer device (or optionally two or more devices) in communication with the vaporizer. For this purpose, the control device 104 can comprise a communication equipment 105. The control device 104 can further comprise a memory 108. A computer device can be a component of a vaporizer system which further comprises the vaporizer 100 , and may include its own communication equipment, which may establish a wireless communication channel with the communication equipment 105 of the vaporizer 100. For example, a computing device used as part of a vaporizer system may include a device general purpose computing (e.g., smart phone, tablet, personal computer, other portable devices such as a smartwatch, or the like) that runs software to produce a user interface to enable a user to device to interact with a vaporizer. In other implementations of the present object, such a device used as part of a vaporizer system may be a dedicated hardware component such as a remote control or another wireless or wired device comprising one or more commands of '' physical or software interface (for example, configurable on a screen or other display device and selectable by user interaction with a touch screen or other input device such as a mouse, pointer, ball , cursor buttons, or the like). The vaporizer may further include one or more output elements or devices 117 for providing information to the user.
A computer device which is part of a vaporizer system as defined above can be used for any one or more functions, such as dosage control (for example, dose monitoring, dose setting, dose limitation, user tracking, etc.), session control (e.g. session tracking, session setting, session limitation, user monitoring, etc.), session control nicotine administration (for example, switching between vaporizable material of nicotine and non-nicotine, adjustment of an amount of nicotine administered, etc.), obtaining location information (for example, location of other users, dealer / retailer locations, vaping locations, relative or absolute location of the vaporizer itself, etc.), customization of the vaporizer (for example, vaporizer name, vaporisa lock / password protection tutor, setting of one or more parental controls, association of the vaporizer with a group of users, registration of the vaporizer with a manufacturer or a maintenance organization under warranty, etc.), participation in social activities (by (e.g. games, social media communications, interaction with one or more groups, etc.) with other users, or the like. The terms "session management", "session", "vaporizer session", or "vaping session" are used generically to refer to a period spent using the vaporizer. The period may include a period of time, a number of doses, an amount of vaporizable material, and / or the like.
In the example in which a computer device provides signals associated with the activation of the resistive heating element, or in other examples of coupling a computer device with a vaporizer for the implementation of different control or other functions, the computing device executes one or more sets of computer instructions to provide a user interface and for the management of underlying data. In one example, the detection by the computer device of a user interaction with one or more user interface elements can cause the computer device to signal to the vaporizer 100 to activate the heating element, ie at a temperature of full operation to create an inhalable dose of vapor / aerosol. Other functions of the vaporizer can be controlled by interaction of a user with a user interface on a computing device in communication with the vaporizer.
The temperature of a resistive heating element of a vaporizer can depend on several factors, including an amount of electrical energy delivered to the resistive heating element and / or a duty cycle to which electrical energy is delivered, the transfer of heat by conduction to other parts of the electronic vaporizer and / or to the environment, latent heat losses due to the vaporization of a vaporizable material from the capillary element and / or of the atomizer as a whole, and convective heat loss due to the flow of air (for example, air moving through the heating element or the atomizer as a whole when a user inhale from the electronic vaporizer). As stated above, to reliably activate the heating element or heat the heating element to a desired temperature, a vaporizer may, in some implementations of the present object, use signals from a pressure sensor to determine that a user is inhaling. The pressure sensor can be positioned in the air flow path and / or can be connected (for example, by a passage or other path) to an air flow path connecting an inlet so that air can enter the device and an outlet through which the user inhales the vapor and / or the resulting aerosol so that the pressure sensor undergoes pressure changes concomitantly with the air passing through the vaporizer device the air inlet to the air outlet. In certain implementations of the present object, the heating element can be activated in association with a puff of a user, for example by automatic detection of the puff, for example by detection by the pressure sensor of a change in pressure in the air flow path.
Typically, the pressure sensor (as well as other possible sensors 113) can be positioned on or coupled (for example, electrically or electronically connected, physically or via a wireless connection) to the device. control 104 (for example, a set of printed circuit boards or another type of circuit board). To accurately measure and maintain the durability of the vaporizer, it may be beneficial to provide an elastic gasket 127 to separate an air flow path from other parts of the vaporizer. The seal 127, which may be a gasket, can be configured to at least partially surround the pressure sensor so that the connections of the pressure sensor to the internal circuits of the vaporizer are separated from a portion of the exposed pressure sensor to the air flow path. In an example of a cartridge-based vaporizer, the gasket 127 may also separate portions of one or more electrical connections between a vaporizer body 110 and a vaporizer cartridge 120. Such arrangements of a gasket sealing 127 in a vaporizer 100 may be useful in controlling potentially disruptive impacts on the components of the vaporizer resulting from interactions with environmental factors such as water in the vapor or liquid phases, other fluids such as the vaporizable material , etc., and / or to reduce the escape of air from the air flow path designed in the vaporizer. Air, liquid or other undesirable fluid passing in front of and / or coming into contact with the vaporizer circuits can cause various undesirable effects, such as a deterioration in pressure readings, and / or can lead to the accumulation of undesirable materials, such as moisture, vaporizable material, etc., in parts of the vaporizer where they can lead to a poor pressure signal, degradation of the pressure sensor or other components, and / or a duration of shorter vaporizer life. Leaks in seal 127 can also lead to a user inhaling air that has passed over parts of the spray device that contain or are made of materials whose inhalation should be avoided.
A general class of vaporizers which have recently gained some popularity includes a vaporizer body 110 which includes a control device 104, a power source 112 (for example, a battery), one or more sensors 113, load contacts, a gasket 127, and a cartridge receptacle 118 configured to receive a vaporizer cartridge 120 for coupling to the vaporizer body via one or more of different attachment structures. In some examples, the vaporizer cartridge 120 includes a reservoir 140 to hold a liquid vaporizable material and a mouthpiece 130 to deliver an inhalable dose to a user. The vaporizer cartridge may include an atomizer 141 having a capillary element and a heating element, or alternatively, one or both of the capillary element and the heating element may be part of the vaporizer body. In implementations in which any part of the atomizer 141 (e.g., the heating element and / or the capillary element) is part of the vaporizer body, the vaporizer may be configured to dispense vaporizable material liquid from a reservoir in the vaporizer cartridge to the atomizer part (s) included in the vaporizer body.
Cartridge-based configurations for vaporizers that generate an inhalable dose of a non-liquid vaporizable material by heating a non-liquid vaporizable material are also within the scope of this subject. For example, a vaporizer cartridge may include a mass of plant material which is processed and formed so as to have direct contact with parts of one or more resistive heating elements, and such a vaporizer cartridge may be configured to be mechanically and electrically coupled to a vaporizer body which includes a processor, a power source, and electrical contacts for connection to corresponding cartridge contacts to complete a circuit with the one or more resistive heating elements.
In vaporizers in which the power source 112 is part of a vaporizer body 110 and a heating element is disposed in a vaporizer cartridge 120 configured for coupling to the vaporizer body 110, the vaporizer 100 may include electrical connection elements (for example, means for completing a circuit) for completing a circuit which includes the control device 104 (for example, a printed circuit board, a microcontroller, or the like), the power source, and the heating element. These elements may include at least two contacts on a lower surface of the vaporizer cartridge 120 (presently called cartridge contacts 124) and at least two contacts disposed near a base of the cartridge receptacle (presently called receptacle contacts 125) of the vaporizer 100 so that the cartridge contacts 124 and receptacle contacts 125 establish electrical connections when the vaporizer cartridge 120 is inserted into and coupled to the cartridge receptacle 118. The circuit supplemented by these electrical connections can allow the distribution of electric current to the resistive heating element and may further be used for additional functions, such as, for example, measuring a resistance of the resistive heating element for use in determining and / or monitoring d '' a temperature of the heating element on the bottom e of a coefficient of thermal resistivity of the resistive heating element, the identification of a cartridge on the basis of one or more electrical characteristics of a resistive heating element or of the other circuits of the vaporizer cartridge, etc.
In some examples of the present object, the at least two cartridge contacts and the at least two receptacle contacts can be configured to be electrically connected in any one of at least two orientations. In other words, one or more circuits necessary for the operation of the vaporizer can be completed by inserting a vaporizer cartridge 120 into the cartridge receptacle 118 in a first rotational orientation (around an axis along which the the end of the vaporizer cartridge comprising the cartridge is inserted into the cartridge receptacle 118 of the vaporizer body 110) so that a first cartridge contact of the at least two cartridge contacts 124 is electrically connected to a first receptacle contact at least two receptacle contacts 125 and a second cartridge contact of the at least two cartridge contacts 124 is electrically connected to a second receptacle contact of the at least two receptacle contacts 125. In addition, the one or more circuits necessary for the operation of the vaporizer can be completed by inserting a vapor cartridge orifice 120 in the cartridge receptacle 118 in a second rotational orientation so that the first cartridge contact of the at least two cartridge contacts 124 is electrically connected to the second cartridge contact of the at least two receptacle contacts 125 and that the second cartridge contact of at least two cartridge contacts 124 is electrically connected to the first receptacle contact of at least two receptacle contacts 125. This feature of a vaporizer cartridge 120 being reversibly insertable into a cartridge receptacle 118 of the body of vaporizer 110 is described further below.
In an example of a fastening structure for coupling a vaporizer cartridge 120 to a vaporizer body, the vaporizer body 110 includes a snap (for example, a notch, a projection, etc.) protruding toward the interior from an internal surface of the cartridge receptacle 118. One or more external surfaces of the vaporizer cartridge 120 may include corresponding recesses (not shown in Figure IA) which can adjust and / or otherwise snap onto such snaps when one end of the vaporizer cartridge 120 is inserted into the cartridge receptacle 118 on the vaporizer body 110. When the vaporizer cartridge 120 and the vaporizer body 110 are coupled (for example, by insertion of a end of the vaporizer cartridge 120 into the cartridge receptacle 118 of the vaporizer body 110, the snap into the vaporizer body 110 p would fit into and / or otherwise be held in the recesses of the vaporizer cartridge 120 to hold the vaporizer cartridge 120 in place when assembled. Such a snap-fit assembly can produce sufficient support to hold the vaporizer cartridge 120 in place to ensure good contact between the at least two cartridge contacts 124 and the at least two receptacle contacts 125, while allowing the release of the vaporizer cartridge 120 of the vaporizer body 110 when a user pulls with reasonable force on the vaporizer cartridge 120 to separate the vaporizer cartridge 120 from the cartridge receptacle 118.
In addition to the description above concerning the electrical connections between a vaporizer cartridge and a vaporizer body being reversible so that at least two directions of rotation of the vaporizer cartridge in the cartridge receptacle are possible, in some vaporizers, the shape of the vaporizer cartridge, or at least one shape of the end of the vaporizer cartridge that is configured for insertion into the cartridge receptacle may have rotational symmetry of at least two-fold. In other words, the vaporizer cartridge or at least the insertable end of the vaporizer cartridge can be symmetrical when rotated 180 ° about an axis along which the vaporizer cartridge is inserted into the receptacle cartridge. In such a configuration, the vaporizer circuits can allow identical operation regardless of the symmetrical orientation presented by the vaporizer cartridge.
In some examples, the vaporizer cartridge, or at least one end of the vaporizer cartridge configured for insertion into the cartridge receptacle may have a non-circular cross section transverse to the axis along which the vaporizer cartridge is inserted into the cartridge receptacle. For example, the non-circular cross-section can be approximately rectangular, approximately elliptical (for example, having an approximately oval shape), non-rectangular but with two sets of opposite sides which are parallel or approximately parallel (for example, having a parallelogram type shape) , or other forms having a rotation symmetry of at least order two. In this context, having approximately a shape indicates that a basic similarity to the described shape is apparent, but that the sides of the shape in question are not necessarily completely linear and the vertices are not necessarily completely acute. The rounding of two or one of the edges or vertices of the cross-sectional shape is envisaged in the description of any non-circular cross-section presently mentioned.
The at least two cartridge contacts and the at least two receptacle contacts can take different forms. For example, one or both of the contact sets may include conductive pins, tabs, terminals, receiving holes for the pins or terminals, or the like. Some types of contacts may include springs or other biasing elements to achieve better physical and electrical contact between the contacts on the vaporizer cartridge and the vaporizer body. The electrical contacts may optionally be gold plated, and / or may include other materials.
Figures IB to 1D illustrate an embodiment of the vaporizer body 110 comprising a cartridge receptacle 118 in which the vaporizer cartridge 120 can be inserted removably. FIGS. 1B and 1C represent top views of the vaporizer 100 illustrating the cartridge being positioned for insertion and inserted, respectively, in the vaporizer body 110. FIG. 1D illustrates the reservoir 140 of the vaporizer cartridge 120 being formed entirely or partly of translucent material so that the level of vaporizable material 102 is visible from a window 132 (for example, of translucent material) along the vaporizer cartridge 120. The vaporizer cartridge 120 can be configured so that the window 132 remains visible when it is received in an insertable manner by a cartridge receptacle 118 of the vaporizer body 110. For example, in a configuration example, the window 132 can be disposed between a lower edge of the mouthpiece 130 and an upper edge of the vaporizer body 110 when the vaporizer cartridge 120 is coupled to the cartridge receptacle 118.
FIG. 1E illustrates an example of an air flow path 134 created during a puff by a user on the vaporizer 100. The air flow path 134 can direct the air to a vaporization chamber 150 (see, for example, Figure 1F) contained in a wick housing where the air is combined with an inhalable aerosol for administration to a user via a mouthpiece 130, which may also be part of the cartridge. vaporizer 120. For example, when a user takes a puff on the vaporizer, the air flow path 134 may pass between an outer surface of the vaporizer cartridge 120 (for example, window 132) and an inner surface a cartridge receptacle 118 on the vaporizer body 110. Air can then be drawn into an insertable end 122 of the cartridge, through the vaporization chamber which includes or contains the element nt heater and wick, and exit through an outlet 136 of the mouthpiece 130 for administration of the inhalable aerosol to a user.
Figure 1F shows additional elements which can be included in a vaporizer cartridge 120 consistent with the present object. For example, the vaporizer cartridge 120 may include a plurality of cartridge contacts (such as cartridge contacts 124) disposed on the insertable end 122, which is configured to be inserted into the cartridge receptacle 118 of a body of vaporizer 110. The cartridge contacts 124 may optionally be part of a single piece of metal which forms a conductive structure (such as conductive structure 126) connected to one of two ends of a resistive heating element. The conductive structure can optionally form opposite sides of a heating chamber and can serve as heat shields and / or heat sinks to reduce the transmission of heat to external walls of the vaporizer cartridge 120. Figure 1F shows in in addition to a cannula 128 in the vaporizer cartridge 120 which defines part of the air flow path 134 between the heating chamber formed between the conductive structure 126 and the mouthpiece 130.
As described in Figure 1E, this configuration causes the air to flow down around the insertable end 122 of the vaporizer cartridge 120 in the cartridge receptacle 118, then flow back into the opposite direction after passing around the insertable end 122 (for example, an end opposite an end that includes the mouthpiece 130) of the vaporizer cartridge 120 as it enters the cartridge body toward the chamber vaporization 150. The air flow path 134 then moves through the interior of the vaporizer cartridge 120, for example through one or more internal tubes or channels (such as cannula 128) and through one or more outlets (such as outlet 136) formed in the mouthpiece 130.
As mentioned above, the entrainment of vaporizable material from the reservoir can create a vacuum in the reservoir, and such a vacuum can reduce or prevent the capillary action produced by the wick. This can reduce the efficiency of the wick for sucking the vaporizable material into the vaporization chamber, thereby reducing the efficiency of the vaporizing device to vaporize a desired amount of vaporizable material, for example when a user takes a puff on the device. of spray bottle. In addition, the vacuum created in the tank can ultimately lead to the inability to suck all of the vaporizable material into the vaporization chamber, thereby wasting vaporizable material. Various elements and devices are described below which improve or solve these problems. For example, various elements are presently described to control the flow of air in a vaporizer device, which can provide benefits and improvements over existing approaches, while introducing additional benefits as described herein.
The vaporizer devices and / or the cartridges presently described comprise one or more elements which control and improve the air flow in the vaporization device and / or the cartridge, thereby improving the efficiency and effectiveness of vaporization of the vaporizable material by the vaporizer device.
Figures 2A and 2B illustrate diagrams of first and second embodiments, respectively, of a reservoir system 200a, 200b configured for a vaporizer cartridge (such as the vaporizer cartridge 120) and / or a device vaporizer (such as vaporizer 100) to improve the air flow in the vaporizer device. More specifically, the reservoir systems 200a, 200b illustrated in Figures 2A and 2B improve the pressure control in the reservoir 240 so that a vacuum created in the reservoir 240 is alleviated after a user takes a puff on the vaporizer device. This allows the capillary action of the porous material (for example, a wick) associated with the reservoir 240 and the vaporization chamber 242 to continue to suck effectively the porous material 202 from the reservoir 240 into the vaporization chamber 242 after each puff.
As described in Figures 2A and 2B, the tank systems 200a, 200b include a tank 240 configured to contain a vaporizable material 202. The tank 240 is sealed on all sides by the walls 232 of the tank except from the passage of a wick which extends between the reservoir and the vaporization chamber 242. A heating element or a heating device can be contained in the vaporization chamber 242 and coupled to the wick. The wick is configured to produce the capillary action which sucks the vaporizable material 202 from the reservoir 240 towards the vaporization chamber 242 to be vaporized in aerosol by the heating device. The aerosol is then combined with the air flow 234 flowing along an air flow passage 238 of the vaporizer for inhalation by a user.
The tank systems 200a, 200b further include an air flow limiter 244 which limits the passage of the air flow 234 along the air flow passage 238 of the vaporizer device, for example when a user takes a puff on the spray device. The limitation of air flow 234 caused by the air flow limiter 244 may allow the formation of a vacuum along a portion of the air flow passage 238 downstream of the air limiter. air flow 244. The vacuum created along the air flow passage 238 can facilitate aspiration of the aerosol formed in the vaporization chamber 242 along the air flow passage 238 for inhalation by an user. At least one air flow limiter 244 can be included in each of the tank systems 200a, 200b and the air flow limiter 244 can include any number of elements to limit the air flow the along the air flow passage 238.
As described in Figures 2A and 2B, each of the tank systems 200a, 200b may further include a vent 246 which can be configured to selectively allow the passage of air in the tank 240 to increase the pressure in the tank 240, for example to relieve the reservoir 240 of a negative pressure (vacuum) resulting from the suction of the vaporizable material 202 from the reservoir 240, as described above. At least one vent 246 can be associated with the reservoir 240. The vent 246 can be an active or passive valve and the vent 246 can include any number of elements to allow air to pass into the reservoir 240 to attenuate the negative pressure created in the reservoir 240. Different embodiments of vents and vent configurations (for example, embodiments of wick housings comprising one or more vents) are described in more detail below.
For example, one embodiment of the vent 246 may include a passage which extends between the reservoir 240 and the air flow passage 238 and includes a diameter which is dimensioned so that a voltage fluid of the vaporizable material 202 prevents the vaporizable material 202 from passing through the passage when the pressure is equalized on either side of the vent 246 (for example, the pressure in the reservoir 240 is approximately the same as the pressure in the air flow passage 238). However, the diameter of the aeration passage can be dimensioned so that a vacuum pressure created in the reservoir 240 breaks the surface tension of the vaporizable material 202 along the aeration passage, thereby allowing an air volume of pass from the air flow passage 238 to the reservoir 240 and attenuate the vacuum pressure. Once the volume of air is added to the reservoir 240, the pressure is again equalized on either side of the vent 246, thereby allowing the surface tension of the vaporizable material 202 to prevent the air from entering the reservoir 240, as well as preventing the vaporizable material from leaking from the reservoir 240 via the ventilation passage. In addition, the ventilation passage may include a length which, in addition to the diameter, defines a volume of fluid which can pass through the vent when a pressure differential is present on either side of the vent. For example, the dimensions of the vent passage diameter may include approximately 0.3 mm to 0.6 mm, and may further include diameters having a dimension which is approximately 0.1 mm to 2 mm. The material of the air passage can also facilitate the control of the vent, such as determining a contact angle between the walls of the air passage and the vaporizing material. The contact angle can have an effect on the surface tension created by the vaporizing material and therefore affect the pressure differential threshold which can be created on either side of the vent before leaving a volume of fluid. cross the vent, as described above. The ventilation passage may include different shapes / sizes and configurations which are within the scope of this description. In addition, various embodiments of cartridges and cartridge parts which include one or more of different vent elements are described in more detail below.
The positioning of the vent 246 (for example, a passive vent) and the air flow limiter 244 relative to the vaporization chamber 242 facilitates efficient operation of the tank systems 200a, 200b. For example, improper positioning of the vent 246 or the air flow limiter 244 can lead to an undesirable leakage of the vaporizable material 202 from the reservoir 240. The present description addresses an effective positioning of the vent 246 and the air flow limiter 244 relative to the vaporization chamber 242 (containing the wick). For example, a low or zero pressure differential between a passive vent and the wick can lead to an efficient reservoir system to attenuate a vacuum pressure in the reservoir and lead to effective capillary action of the wick while preventing leakage. Configurations of the reservoir system having effective positioning of the vent and the air flow limiter relative to the vaporization chamber are described in more detail below.
As described in FIG. 2A, the air flow limiter 244 is positioned upstream of the vaporization chamber 242 along the air flow passage 238 and the vent 246 is positioned along the reservoir 240 so that it allows fluid communication between the reservoir 240 and a portion of the air flow passage 238 which is downstream of the vaporization chamber 242. Therefore, when a user takes a puff on the vaporization device, a negative pressure is created downstream of the air flow limiter 244 so that the vaporization chamber 242 is subjected to a negative pressure. Similarly, one side of the vent 246 in communication with the air flow passage 238 also experiences negative pressure. Consequently, a small to zero amount of pressure differential is created between the vent 246 and the vaporization chamber 242 during the puff (for example, when the user extracts or draws air from the vaporization device). However, after the puff, the capillary action of the wick sucks the vaporizable material 202 from the reservoir 240 towards the vaporization chamber 242 to replenish the vaporizable material 202 which has been vaporized and inhaled as a result of the previous puff. As a result, a vacuum or negative pressure is created in the reservoir 240. A pressure differential then occurs between the reservoir 240 and the air flow passage 238. As described above, the vent 246 can be configured so that a pressure differential (for example, a pressure difference threshold) between the reservoir 240 and the air flow passage 238 allows a volume of air to pass from the air flow passage 238 in the reservoir 240, thus reducing the vacuum in the reservoir 240 and restoring an equalized pressure on either side of the vent 246 and a stable reservoir system 200a.
In another embodiment, as described in FIG. 2B, the air flow limiter 244 is positioned downstream of the vaporization chamber 242 along the air flow passage 238 and the vent 246 is positioned along the reservoir 240 so that it allows fluid communication between the reservoir 240 and a portion of the air flow passage 238 which is upstream of the vaporization chamber 242. Therefore, when a user takes a puff on the vaporization device, the vaporization chamber 242 and the vent 246 undergo little or no suction or negative pressure as a result of the puff, thus leading to a low or zero pressure differential between the vaporization chamber 242 and the vent 246. Similarly to the case in FIG. 2A, the pressure differential created on either side of the vent 246 will be a consequence of the capillary action of the wick sucking the vaporizable material 202 towards the vaporization chamber 242 after the puff. As a result, a vacuum or negative pressure is created in the tank 240. A pressure differential then occurs on either side of the vent 246. As described above, the vent 246 can be configured so that '' a pressure differential (for example, a pressure difference threshold) between the tank and the air flow passage or the atmosphere allows a volume of air to pass through the tank, thereby reducing the vacuum in The reservoir. This will equalize the pressure on either side of the vent and stabilize the tank system 200b.
The vent 246 can include different configurations and different elements and can be positioned at different positions along the cartridge, so as to obtain different results. For example, one or more vents 246 may be positioned adjacent to or form part of the vaporization chamber or the wick housing. In such a configuration, the one or more vents may allow the communication of fluid (for example, air) between the reservoir and the vaporization chamber (which the air flow passes through when a user takes a puff on the vaporizer and which is therefore part of the air flow path). Similarly, as described above, a vent placed adjacent to or forming part of the vaporization chamber or wick housing may allow air from inside the vaporization chamber to move through the reservoir via the vent to increase the pressure inside the reservoir, thereby effectively reducing the vacuum pressure created as a result of the suction of the vaporizing fluid into the vaporization chamber. Consequently, the attenuation of the vacuum pressure allows a continuous and effective capillary action of the vaporization fluid in the vaporization chamber via the wick to create an inhalable vapor during successive puffs on the vaporization device by a user. Various examples of embodiments of a vaporization chamber ventilation element which includes a wick housing (which houses the vaporization chamber) and at least one vent coupled to or forming part of the housing are described below. wick to obtain efficient ventilation of the above tank.
FIGS. 3A and 3B show an embodiment of a vaporization chamber ventilation element 370. The vaporization chamber ventilation element 370 comprises a wick box 360 and an embodiment of a vent 346 which includes an air passage 376 formed of a tube 375 extending through and coupled to a portion of the wick housing 360, as described in Figure 3A. At least one vent 346 may be included in the vapor chamber vent member 370, such as two vents 346 positioned on opposite sides of the wick housing
360, as described in Figures 3A and 3B. The wick housing 360 is configured to contain at least a portion of the spray chamber 342, which may include a wick and a heating element coupled to the wick, as described above. For example, the wick housing 360 includes at least one wick passage 368 which allows a wick to extend (for example, along the longitudinal axis L) between the vaporization chamber 342 and the reservoir, thereby allowing the wick to suck a vaporizable material from the reservoir into the vaporization chamber 342.
The wick housing 360 further includes a portion of the air flow passage 338, comprising an air flow coupling member 372 configured to couple (for example, by pressure adjustment, or the like) a cannula thereto to form another part of the air flow passage 338. Therefore, when a user takes a puff on the vaporizer device, an air flow is transferred along the air passage air flow 338, including through the vaporization chamber 342 where it combines with the aerosol formed by the heating element vaporizing the vaporizable material saturating the wick. As described above, after the puff, when the capillary action of the wick sucks a vaporizable material from the reservoir towards the vaporization chamber 342, thus creating a vacuum in the reservoir, the vent 346 can let a volume of air get move from the vaporization chamber 342 (or the air flow passage 338) to the reservoir, thereby reducing the vacuum in the reservoir and equalizing the pressure between the vaporization chamber 342 and the reservoir.
The tube 375 forming the ventilation passage 376 of the vent 346 may comprise a first end 377 positioned adjacent to or in the air flow passage 338 or the vaporization chamber 342 and a second end 378 disposed in the tank. The tube 375 can include different shapes and sizes for aerating the tank. As described above, the ventilation passage 376 can be configured (for example, have a diameter) such that the surface tension of the vaporizable material prevents leakage of the vaporizable material in the vaporization chamber but allows the rupture of the surface tension. to allow a volume of air to pass through the ventilation passage and into the tank once a pressure differential threshold is reached on either side of the vent (for example, a vacuum is formed in The reservoir). The vent tube 375 can be made from one or more of different materials, such as different metals and / or plastics.
FIGS. 4A and 4B show another embodiment of a vaporization chamber ventilation element 470 comprising a wick box 460 and another embodiment of a vent 446. The vent 446 illustrated in Figures 4A and 4B includes at least one ventilation passage 476 extending through the wick housing
460, such as two ventilation passages molded into the wick housing 460 and extending parallel to the air flow coupling element 472. As described in FIG. 4B, a first end 477 of the passage aeration 476 may be positioned adjacent to the air flow passage 438 and the vaporization chamber 442, and a second end 478 of the ventilation passage 476 may be in communication with the reservoir. As described above, the wick housing 460 is configured to contain at least a portion of the vapor chamber 442, which may include a wick and a heating element coupled to the wick. For example, the wick housing 460 includes at least one wick passage 468 which allows a wick to extend (e.g., along the longitudinal axis L) between the vaporization chamber 442 and the reservoir, thereby allowing the wick to suck a vaporizable material from the reservoir into the vaporization chamber 442. The wick housing 460 further includes a portion of the air flow passage 438, comprising an air flow coupling member 372 configured to couple (for example, by pressure fit, or the like) a cannula thereto to form another part of the air flow passage 438. Therefore, the vent 346 may leave a volume of air moving from the vaporization chamber 442 (or the air flow passage 438) to the reservoir, thereby reducing the vacuum in the reservoir and equalizing the pressure between the vaporization chamber and the reservoir, as described above above. Air passage 476 may include various shapes and sizes, including those described above.
FIGS. 5A and 5B represent another additional embodiment of a vaporization chamber ventilation element 570 comprising a wick box 560 and another embodiment of a vent 546. The vent 546 illustrated in FIGS. 5A and 5B comprises at least one ventilation passage 576 molded in and extending through the wick box 560, such as two ventilation passages 576 extending parallel to the longitudinal axis L of the passage of wick 568. As depicted in FIG. 5B, a first end 577 of the air passage 576 is positioned adjacent to or in communication with the air flow passage 538 and the vapor chamber 542, and a second end 578 of the ventilation passage 576 is in communication with the tank.
After the puff, when the capillary action of the wick sucks a vaporizable material from the reservoir towards the vaporization chamber 542, thus creating a vacuum in the reservoir, the vent 546 can allow a volume of air to move from the vaporization chamber 542 (or the air flow passage 538) to the reservoir, thereby reducing the vacuum in the reservoir and equalizing the pressure between the vaporization chamber 542 and the reservoir. Air passage 567 can include various shapes and sizes, including those described above.
FIGS. 6A and 6B show an embodiment of a cartridge 620 comprising an embodiment of a vaporization chamber aeration element 670. The vaporization chamber aeration element 670 can comprise a wick housing 660 and an embodiment of a vent 646. The vent 646 illustrated in Figures 6A and 6B comprises at least one ventilation passage 676 extending along an external surface (for example, the along one or more sides) of the wick housing 660. As depicted in Figure 6B, the air passage 676 may include a channel (e.g., U-shaped) extending along an outer corner wick housing 660. In addition, the ventilation passage 676 can be defined between a wall or an internal element of the reservoir 640. Consequently, the ventilation passage 676 extends between and is defined, at least in part by, the channel extending along the housing wick and an internal wall of the reservoir 640. As described in FIG. 6B, a first end 677 of the ventilation passage 576 is positioned adjacent to or in communication with the air flow passage 638 and the vaporization 642, and a second end 678 of the ventilation passage 676 is in communication with the tank. Figures 6A and 6B illustrate the ventilation passage 676 positioned along opposite front corners of the wick housing. FIGS. 7A and 7B illustrate another embodiment of the cartridge 720 comprising a vaporization chamber ventilation element 770 similar to the vaporization chamber ventilation element 670 of FIGS. 6A and 6B, but with the vent 746 positioned along diagonal corners of the drill bit housing 760.
Similarly to what is described above, when a user takes a puff on the vaporizer device, an air flow is transferred along the air flow passage 638 and through the vaporization chamber 642 of the cartridge 620 (or, similarly, the cartridge 720) where it combines with the aerosol (for example, formed by the heating element vaporizing the vaporizable material saturating the wick 662). After the puff, when the capillary action of the wick 662 sucks a vaporizable material from the reservoir 640 towards the vaporization chamber 642, thus creating a vacuum in the reservoir 640, the vent 646 can allow a volume of air to move from the vaporization chamber 642 (or the air flow passage 638) to the reservoir 640, thus reducing the vacuum in the reservoir 640 and equalizing the pressure between the vaporization chamber 642 and the reservoir 640. The passage of aeration 667 may include various shapes and sizes, including those described above. For example, the ventilation passage 667 may include a diameter which is dimensioned so that a surface tension of the vaporizable material contained in the reservoir prevents the passage of fluid (e.g., the vaporizable material or air) as long as a pressure differential threshold is not created on either side of the vent, for example when a vacuum is created in the tank, as described above.
FIGS. 8A and 8B represent another embodiment of a vaporization chamber ventilation element 870 of a cartridge 820 which is similar to the vaporization chamber ventilation element 670 illustrated in the figures 6A and 6B such that the wick housing 860 includes at least one air passage 876 extending along an outer surface (for example, along one or more sides) of the wick housing 860. As described in FIG. 8B, the wick box 860 comprises a chamfered corner or edge which at least partially defines the ventilation passage 876. In addition, the ventilation passage 876 can be defined between a wall or an internal element of the tank 840. Consequently, the ventilation passage 876 extends between and is defined, at least in part, by the chamfered corner or edge of the wick box 860 and an internal wall of the reservoir 840. As described in FIG. 8B, a first the end 877 of the air passage 876 is positioned adjacent to or in communication with the air flow passage 838 and the vapor chamber 842, and a second end 878 of the air passage 876 is in communication with the reservoir 840. FIGS. 8A and 8B illustrate the ventilation passage 876 positioned along a front corner of the wick box 860. FIGS. 9A and 9B illustrate another embodiment of the cartridge 920 comprising an element of vapor chamber vent 970 similar to the vapor chamber vent element 870 of Figures 8A and 8B, but with the vent 946 positioned along diagonal corners of the wick housing 960.
Similarly to what is described above, when a user takes a puff on the vaporizer device, an air flow is transferred along the air flow passage 838 and through the vaporization chamber 842 of the cartridge 820 (or, similarly, the cartridge 920) where it combines with the aerosol (for example, formed by the heating element vaporizing the vaporizable material saturating the wick 862). After the puff, when the capillary action of the wick 862 sucks a vaporizable material from the reservoir 840 towards the vaporization chamber 842, thus creating a vacuum in the reservoir 840, the vent 846 can allow a volume of air to move from the vaporization chamber 842 (or the air flow passage 838) to the reservoir 840, thereby reducing the vacuum in the reservoir and equalizing the pressure between the vaporization chamber 842 and the reservoir. Air passage 867 can include various shapes and sizes, including those described above.
FIG. 10 shows another embodiment of a spray chamber ventilation element 1070 comprising a wick box 1060 and another embodiment of a vent 1046. The vent 1046 illustrated in the figure 10 includes two air passages 1076 molded into the wick housing 1060. In addition, the air passages 1076 extend parallel to and merge with the air flow coupling member 1072 configured to couple (by example, by pressure fit, or the like) a cannula thereto to form another part of the air flow passage 1038. Therefore, when the cannula is coupled to the flow coupling element air 1072, the air passage 1076 can extend along the side of the cannula and extend between the reservoir and the vaporization chamber 1042.
FIG. 11 shows another embodiment of a vaporization chamber ventilation element 1170 comprising a wick box 1160 and another embodiment of a vent 1146. The vent 1146 illustrated in the figure 11 includes an air passage 1176 molded into the wick housing 1060. In addition, the air passage 1076 extends parallel to and merges with the wick passage 1168 configured to allow a wick to extend along of it. Therefore, when the wick is coupled to and extends along the wick passage 1168, the air passage 1176 can extend along the side of the wick and extend between the reservoir and the spray chamber. 1142.
In some implementations, a flattened wick design can be used. The flat surface sides may have an increased surface area compared to conventional cylindrical wicks, thereby producing increased vapor distribution from the reservoir to the vaporization chamber. A flattened wick design can have favorable capillary properties based on the geometry, and can also improve manufacturing (for example, based on ease of insertion, ability to cut, etc.). In some implementations, a heating element, such as a coil or wire, can be placed along one or more of the sides of the wick. In some implementations, the heating element can be wrapped around the wick. The wick can be formed from one or more different materials, such as silica, cotton, glass fibers, etc. In certain aspects, cotton wicks can produce a capillary action superior to that of wicks made of other materials, thus favoring the obtaining of an increased distribution of vapor from the reservoir to the vaporization chamber.
FIG. 12A represents a cartridge 1220 inserted into a vaporizer device 1200, with the cartridge comprising an embodiment of a flattened wick 1262. In certain implementations, the flattened wick 1262 can be placed close to an insertable end 1222 of the cartridge 1220 and in fluid communication with the reservoir 1240. FIG. 12B illustrates a close-up perspective view of the flattened wick 1262, consistent with implementations of the present object. As depicted in Figure 12B, the flattened drill bit 1262 may include an upper surface 1264 and a lower surface 1266 which are flat and mutually parallel. The sides 1268 of the flat drill bit 1262 can be angled or parallel to each other. One or more corners of the flattened drill bit can be bent relative to the upper or lower surface, and can be chamfered, as described in Figure 12B. Other implementations of the 1262 flat drill bit are within the scope of this description.
The control and / or facilitation of the air flow through the air flow passage of the cartridge and / or the control of the air pressure in certain parts of the cartridge can facilitate the suction of vaporizable material into the vaporization chamber to thereby ensure the production of a desired amount of aerosol by the vaporizer device. Some implementations of the present object described here include one or more air control elements which allow air to passively and / or actively enter the tank to replace the vaporizable material leaving the tank. Such configurations can be allowed and / or facilitated by the negative pressure created by a user puffing on the vaporizer device, as described in more detail below.
In some implementations, one or more parts of a cartridge (for example, a reservoir) may include one or more air flow control elements, which may include one or more of the different embodiments currently described. The air flow control element can help control air flow using different mechanisms, such as passive flow systems, passively energized but actively controlled systems, and / or active systems, between other. Different embodiments of an air flow control element are described in more detail below.
FIG. 13A illustrates a cartridge 1320 consistent with implementations of the present object and FIG. 13B illustrates a close-up view of a diagram of a vaporization chamber 1342 of the cartridge 1320 consistent with implementations of the present object. The cartridge 1320 comprises a reservoir 1340 for holding a vaporizable material 1302, a mouthpiece 1330, an air flow passage 1338 (defined by a cannula 1328) through the reservoir 1340, a wick box 1360, and / or a capillary element (for example, a wick) 1362. The wick 1362 is coupled to a resistive heating element (for example, a coil) which is connected to one or more electrical contacts (for example, plates 1326) and a power supply. A vaporization chamber or a heater 1350 of the cartridge 1320 can comprise the wick 1362 extending between the plates 1326, as well as the resistive heating element in contact with the plates 1326 and the wick 1362. The wick housing 1360 can surround at least part of the heating device 1350 and / or at least part of the cannula 1328 with the air flow passage 1338.
The wick 1362 can suck the vaporizable material 1302 from the reservoir 1340, from one or both ends of the wick 1362 and / or radially along a length of the wick 1362 thanks to, at least in part , material from wick 1362 and / or perforations in wick 1362. When a user takes a puff on the mouthpiece 1330 of the cartridge 1320, air flows into the cartridge 1320 through an inlet . The heating element can be activated, for example, by a pressure sensor, a push button, a motion sensor, a flow sensor, or some other approach to detect that a user is taking a puff or inhaling otherwise via a flow path of the vaporizer device. When the heater is turned on, the coil may experience a temperature increase as a result of the current flowing through the heater to generate heat. Heat is transferred to at least part of the vaporizable material in wick 1362 via heat transfer by conduction, convection and / or radiating so that at least part of the vaporizable material is vaporized. The air entering the vaporizer device flows over the heated wick / heating element, so as to remove the vaporizable vaporizable material, where it is condensed and exits in the form of an aerosol through the mouthpiece 1330 to a user.
A wick 1362 consistent with implementations of the present object can constitute a capillary path, for the material vaporizable in the reservoir 1340, through and / or inside the wick 1362. The capillary path is generally sufficient large to allow capillarity to replace the vaporized liquid transferred from the reservoir by capillary action during use of the vaporizer device, but may be small enough to prevent leakage of vaporizable fluid material from the vaporizer cartridge during operation normal, for example when applying pressure (for example, compression) to the vaporizer cartridge. The wick 1360 and / or wick 1362 can be treated to prevent leakage. For example, the wick 1362 and / or the wick box 1360 can be coated after filling to prevent leaks and / or evaporation via the wick 1362 until activation by connection to a vaporizer body. and / or applying current through the plates 1326 (for example, operating in a vaporizer device), or otherwise using the vaporizer cartridge. Any suitable coating can be used, including a thermally vaporizable coating (e.g., wax or other material) or the like.
A wick consistent with implementations of the present object can have an orientation other than that described in the illustrations of the example of cartridge of FIGS. 13A and 13B. For example, the wick 1362 shown in Figures 13A and 13B extends horizontally between two side portions of the vaporizer cartridge. However, the wick is not limited to this orientation and may, for example, extend internally along a length of the vaporizer cartridge with the heating element at one end of the wick. Other orientations and configurations are also possible.
Passive systems for controlling air flow through the air flow control element 1344 may include a pore and / or a check valve, among other configurations. For example, the air flow control element 1344 may include a pore which includes an opening extending through a wall of the reservoir and / or cartridge. The wall may include a wall thickness that extends from an inner surface of the reservoir and / or the cartridge body to an outer surface of the reservoir and / or the cartridge body. The air flow control element 1344 can be formed and / or sized so that the surface tension can hold the vaporizable material in the reservoir 1340. For example, the air flow control element 1344 can be circular. Other shapes and configurations are within the scope of this description.
In certain implementations, the positioning of the air flow control element 1344 at certain locations along the cartridge can improve and / or otherwise increase the efficiency and the effectiveness of vaporization of the material. sprayable. For example, placing the pore away from the ends of the wick 1362 can prevent or limit the drying of each end of the wick 1362 by providing an alternative air intake path. In such configurations, the air flow control element 1344 can be positioned in a location so that an outer side of the air flow control element 1344 is exposed to higher pressure ( for example, closer to atmospheric pressure) to that to which wick 1362 is exposed during a puff. In certain implementations, the air flow control element 1344 can be positioned upstream of the wick 1362 (for example, above the wick 1362 as described in the orientation of FIGS. 13A and 13B) . In certain implementations, at least one flow limiter, such as a microperforation and / or an electrical contact pad, positioned at the level of the lower part of the vaporizer cartridge, can be positioned between the wick and the pore. .
The positioning of the air flow control element 1344 upstream of the wick 1362 along the air flow passage 1338 can force the air outside the pore in the reservoir 1340 during and / or after a puff. In such configurations, at least during the puff, the air positioned outside the pore has a higher pressure than the air positioned inside the reservoir 1340. The pressure differential between the air at the outside the reservoir 1340 and the air inside the reservoir 1340 can cause the pore to define a primary air inlet, when the air passes into the reservoir 1340 through the pore. Such configurations may desirably create a high and / or adjustable amount of additional pressure to force the vaporizable material in wick 1362 beyond what would naturally be transported by capillary pressure. Consequently, the total vaporization rate of the material vaporizable during a puff may not be limited by the properties of the wicking material alone. Instead, the total vaporization rate of the material vaporizable during a puff can be desirably controlled and / or modified by incorporating an air flow control element 1344 and / or placing the air flow control element 1344 at a desired location.
As mentioned above, the placement of the air flow control element 1344 can improve and / or increase the vaporization rate of the vaporizable material at least during and / or after a puff. In some implementations, the air flow control element 1344 may be placed near and / or between the ends of the wick 1362. In some situations, placing the air flow control element air 1344 at a high distance from the wick 1362, for example at an upper end portion of the reservoir 1340, a hydrostatic differential pressure between the air flow control element 1344 and the wick 1362 can allow air entering reservoir 1340 and vaporizable material being drained out of wick 1362. The additional hydrostatic differential pressure may undesirably cause too much vaporizable material to be drained out of the wick, for example at a rate faster or much faster than that at which the vaporizable material is vaporized, depending on the orientation of the vaporizer cartridge Eur. In some implementations, a high hydrostatic differential pressure can undesirably cause all of the vaporizable material in the tank to be drained. If the distance between the air flow control element 1344 and the wick is relatively small (for example, relative to the distance between the ends of the wick), the additional hydrostatic differential pressure may be negligible. Such configurations can help limit or prevent leakage of the vaporizable material. Consequently, it may be desirable for the air flow control element 1344 to be positioned on the gravitational plane, close to the wick 1362, for example at the level of and / or adjacent to the wick housing 1360, between the ends of the wick 1362, and / or upstream of the wick 1362, for example in the air flow passage 1338.
In some implementations, the air flow control element 1344 may include a valve, such as a duckbill valve or a check valve, among other valves. The 1344 air flow control element including the valve can be desirably positioned at identical and / or similar locations to those described above. The valve can allow air to enter the 1340 tank, but limit or prevent the escape of air from the 1340 tank.
The valve of the air flow control element 1344 may include a cracking pressure. The cracking pressure can be the minimum upstream pressure at which the valve will operate (for example, by letting air pass through). The positioning of the air flow control element 1344 having the valve close to the gravitational plane of the wick 1362, for example at and / or adjacent to the wick housing 1360, between the ends of the wick 1362 , upstream of the wick 1362, for example in the air flow passage 1338, and / or at an external edge of the cartridge 1320, such as a lower corner of the vaporizer cartridge, among others positions, can cause the cracking pressure to be close to zero or negligible pressure. Such configurations may be desirable since the pressure differential created by the capillary pressure of the wick may be small. If the cracking pressure is too high, the valve on the air flow control element 1344 may not crack (for example, open) and may not allow air to pass through the valve .
[0116] In some implementations, the air flow control element 1344 may include an aeration material or a membrane. The aeration material or membrane can be positioned over an opening in the cartridge, such as an outer surface of the pore. The aeration material may include an expanded polytetrafluoroethylene (PTEE) surface, among other materials. The aeration material or membrane can allow air to enter the tank and / or can help limit or prevent the release of vaporizable material from the tank. The aeration material may be desirably positioned in an identical and / or similar location as described above. For example, in some embodiments, the aeration material or the membrane may act as a thermal seal on the pore.
Passively energized but actively controlled systems for controlling the air flow through the air flow control element 1344 may include a magnetic diaphragm valve, a bent nose valve, and / or a passive septum system, among other configurations. At least part of the magnetic diaphragm valve, the bent nose valve and / or the passive septum system can be positioned in a location identical and / or similar to that described above.
In some implementations, the passive septum system may include a septum, such as a resealable perceivable elastomer septum. The septum can be positioned at a bottom, such as a bottom side of the vaporizer cartridge. In such configurations, the vaporizer device may include a needle which pierces the septum upon insertion of the vaporizer cartridge into the vaporizer device. The passive septum system may include a vent, among other components. The vent can be positioned under the needle when it is assembled. The vent may desirably direct the flow of air to the environment. Such configurations can allow ventilation directly to the environment, even in situations where the air pressure outside the vaporizer cartridge is lower.
In some implementations, the passive septum system may include a valve. The valve may desirably control the flow of air through the tank. For example, the valve can be controlled mechanically and / or electronically. In some implementations, the passive septum system includes a microprocessor. The microprocessor can desirably open and / or close the valve. By controlling the operation of the valve, the microprocessor can control a flow of air and / or liquid into or out of the tank, such as an average flow of air and / or liquid. Such configurations can allow easier estimation of the vaporization rate by means of power and / or temperature measurements from the heating element using one or more sensors, for example. Such configurations may desirably allow the valve to be closed when the vaporizer device is not in use, so as to minimize the exchange of oxygen and / or moisture with the environment. Such configurations can desirably extend the life of the cartridge.
Active systems for controlling the flow of air through the air control element may include an active septum system, among other configurations. The active septum system may include a septum, such as a resealable pierceable elastomer septum. The septum can be positioned at a lower part of the cartridge, such as a lower side of the vaporizer cartridge. In such configurations, the vaporizer device may include a needle which pierces the septum upon insertion of the vaporizer cartridge into the vaporizer device.
In some implementations, the passive septum system may include a pump. The pump may desirably control the flow of air through the tank. For example, the pump can be controlled mechanically and / or electronically. In some implementations, the active septum system includes a microprocessor. The microprocessor can desirably start and / or start the pump. The microcontroller can determine an appropriate amount of air to pump into the tank to achieve a desired vaporization rate. In such configurations, the air flow through the system, desirably, may not depend or may depend minimally on the negative pressure applied by the user during a puff. Instead, the pump can directly control the air flow and allow more or less air flow than would be passively driven by the user’s puff and an open valve, for example. In certain implementations, the pump can reduce the mechanical complexity of the air flow control element and / or can allow the use of a high frequency and / or short stroke pump, such as a PCB scale piezoelectric pump. The piezoelectric pump can create a high flow rate and / or can maximize the air pressure to desirably control the flow of air and / or liquid through the system.
Separate vapor path [0122] It may be desirable to avoid leakage from the tank to the environment and / or to other parts of the vaporizer cartridge. The vaporizer cartridge can be pressurized by an air seal positioned at an opposite end of the vaporizer cartridge from the heater. The air seal can create a rear void to help limit or prevent leaks and retain vaporizable material in the tank. In some embodiments, the vaporizer device includes a pressure sensor. The pressure sensor can determine whether the vaporizer device, such as the heater, should be activated, for example, by determining whether a user is taking a puff. The pressure sensor may be based on a pressure signal caused by the flow of air in communication with the pressure sensor. The pressure signal may be deficient when the liquid follows the same path, for example when the pressure sensor is damaged and / or the sensitivity of the pressure sensor is reduced.
Some vaporizer cartridges include a single air flow path that extends through the vaporization chamber and directly outside to the user, such as through a center of the reservoir. The air path can transfer the pressure signal caused by user breathing to the pressure sensor, by transporting steam from the heater to the user, mixing steam with cold air to condensing the vapor in an aerosol, and / or supplying the air which will be injected into the tank during or after the puff. The vaporizable material which leaves the reservoir may not become vaporized and the vaporizable material which recondenses in the air flow passage may be freely able to flow to the pressure sensor, which may damage the pressure sensor. pressure. The surface tension of vaporizable material blocking the pressure sensor can undesirably reduce the pressure signal and / or reduce the ability of the vaporizer device to be properly activated. The description given below includes embodiments of a vaporizer which include a separate pressure sensing path which solves the above problems.
FIG. 14A illustrates a diagram of a cartridge 1420 and of a vaporizer device 1400 according to implementations of the present object. FIG. 14B illustrates a diagram of the cartridge 1420 inserted in a vaporizer device 1400 according to implementations of the present object. As described in FIGS. 14A and 14B, the cartridge 1420 can comprise a reservoir 1440 and / or a vaporization chamber or a heating device 1450. The reservoir 1440 can be at least partially surrounded by an air flow passage 1438 The air flow passage 1438 may include a pressure path 1452 and / or a vapor path 1454. The vaporizer device 1400 may include a pressure sensor 1414 and / or a vapor delivery liner 1456.
FIG. 14B illustrates an example of air flow which passes through the air flow passage 1438 from the assembly of the cartridge 1420 and from the vaporizer device 1400. The air can enter the assembly through an inlet 1448, pass through an air flow passage 1438, pass through the heater 1450, pass through the steam delivery liner 1456, pass through the vapor path 1454, and / or pass through an exit 1436. Additionally , a pressure path 1452 is a separate air channel which extends between the outlet of the cartridge and the pressure sensor 1414, as depicted in FIG. 14B. This allows the pressure sensor 1414 to measure the pressure signal as a static or quasi-static measurement rather than a dynamic measurement. Static measurement can be more accurate than dynamic measurement of the pressure signal.
FIG. 14C illustrates a schematic example of a pressure sensor 1414 positioned at different locations in the air flow passage 1438 and different restrictions in the cartridge 1420. In certain implementations, the pressure sensor 1414 can measure a pressure signal at P _sig i. The pressure signal at P _sig i represents the pressure decrease between a pressure P! at the inlet and a pressure Pi at a first location along the air path. The pressure signal measured by the pressure sensor 1414 may be weak if the resulting resistance between the input (at PO and the first location (at P _x ) is high relative to the intensity of the puff of the user. Therefore, it may be undesirable to position the pressure sensor 1414 near the inlet. In addition, it may be desirable to position the pressure sensor 1414 further downstream in the air flow passage 1438 at a second location (at P ₂ ) for measuring a pressure signal P _sig2 . The pressure path 1452 may have a small diameter compared to a volume of the cartridge 1420 since the pressure path 1452 does not necessarily transmit a significant amount of air flow. The additional separate pressure path air channel 1452 can occupy minimal space in the cartridge 1420, thereby reducing the overall size of the cartridge 1420. In some nes implemented, the pressure path 1452 comprises a diameter which is smaller than a diameter of the vapor path 1454. In some implementations, the diameter of the pressure path 1452 is equal to or greater than the diameter of the vapor path 1454. The separate air channel may desirably separate the vaporizable vaporized material 1402 crossing the vapor path 1454 from the pressure path 1452 which leads to the pressure sensor 1414. Such configurations may desirably extend the life of the pressure sensor and improve the pressure readings, so as to improve the operation of the vaporizer device.
In some implementations, it may be desirable to position the inlet 1448 and the outlet 1436 on the same side of the cartridge 1420. Direct air directly from the inlet 1448 towards the outlet 1436 rather than through a reservoir may allow the cartridge 1420 to be more easily sealed at the top of the reservoir 1440. In some implementations, the cartridge 1420 may include a seal, such as a seal of surface to seal entry 1448 and / or exit 1436.
For example, FIG. 14D represents the cartridge 1420 and the vaporizer device 1400 in a first position in which the inlet and the outlet are hermetically sealed (for example, preventing the flow of air between them) . As depicted in Figure 14D, the cartridge 1420 is pushed further into the vaporizer 1400 to seal the inlet 1448 and / or the outlet 1436, which are positioned along opposite sides of the cartridge 1420. Such configurations allow to obtain a better seal when the cartridge 1420 is not in use, for example when the vaporizer device 1400 is stored and / or between puffs or uses. Such configurations can extend the life of the 1420 cartridge. For example, the gasket helps limit or prevent moisture from entering and / or exiting the vaporizer cartridge. The seal can, desirably, help limit or prevent leakage from the tank. The seal may desirably limit or prevent unwanted air from mixing with the vaporizable material. During use, the cartridge can be positioned in a second position (for example, as described in Figure 14E) in which the inlet and outlet are open, thus allowing the flow of air between them.
FIG. 14D schematically illustrates an example of an assembly of the cartridge 1420 and of the vaporizer device 1400 according to implementations of the present object. The cartridge 1420 comprises a reservoir 1440 and / or a heating device 1450.
The reservoir 1440 is at least partially surrounded by an air flow passage 1438. The air flow passage 1438 comprises a pressure path 1452, a vapor path 1454, and / or a cooling path 1458. The vaporizer device 1400 includes a pressure sensor 1414 and / or a vapor delivery liner 1456.
FIG. 14E illustrates an example of air flow which passes through an air flow passage 1438 from the cartridge and a set of vaporizer device 1400. Air enters the cartridge assembly and of vaporizer 1400 through inlet 1448, passes through an air flow passage 1438 and passes through the pressure sensor 1414 at one end of the pressure path 1452. The air then passes through the heater 1450 , through the steam routing liner 1456, through the steam path 1454, and finally exits through an outlet 1436. The cartridge may include an inlet and / or a secondary air flow passage which includes a flow of air that does not pass through the heater or vaporization chamber and, instead, merges with the aerosol containing the air flow (for example, merges with the air flow that has already crossed the room vaporization bre). For example, air can enter the air flow passage 1438 through a second inlet 1449, as depicted in Figure 14E. The air passing through the second inlet 1449 can pass through the cooling path 1458 and into the vapor path 1454 to mix with the vaporizable vaporizable material 1402 in the vapor path 1454.
The cooling path 1458 may desirably allow the vaporizable vaporized material to mix with a larger volume of cooling air before the flow of mixed air reaches the user. Mixing the vaporizable vaporized material with the volume of cooling air can cause the mixed air to condense and / or create visible vapor. The cooling path 1458 can allow a separate amount of air to flow through the heater 1450 compared to an amount of air that the user draws in during a puff. For example, the user may prefer a certain flow rate and / or a certain reduction in pressure during a puff. In certain situations, the user may prefer a higher flow rate than that which is required to obtain a high vaporization rate at the level of the heating device 1450. The cooling path 1458 can thus make it possible to use different flow rates and pressure reductions to get desired user experiences.
The separation of the cooling air from the air flow which moves over the heater can desirably provide design flexibility. In some implementations, the cooling air can be routed separately to allow the air flow over the heater to be routed through one or more valves, such as check valves (not shown). This can allow the vaporizable material in the tank to be sealed, except during a puff, which allows the vaporizer device to have high barriers against moisture and / or oxygen between uses. Such configurations can desirably control the air pressure at the heater, for example through the valves. Such configurations may desirably limit the amount of vaporizable material that is drawn from the reservoir so that the amount of vaporizable material drawn is less than or equal to the amount of vaporizable material that the heater can vaporize.
Examples of Liquid Nicotine Formulations [0133] Included here are, among others, liquid nicotine formulations for use in electronic vaporizers, such as the devices presently described. In embodiments, a liquid nicotine formulation includes nicotine and an acid such as an organic acid. In embodiments, a liquid nicotine formulation comprises a liquid vehicle.
Nicotine is a chemical stimulant and increases, for example, heart rate and blood pressure when supplied to an animal, for example, a mammal such as a human. The stimulating effect of nicotine may be referred to herein as the stimulating effect of nicotine. In some embodiments, the stimulating effect is correlated with serum nicotine levels. In embodiments, the transfer of nicotine to a subject is associated with a feeling of physical and / or emotional satisfaction. In embodiments, the devices and formulations presently described are useful in reducing the urge of a user to smoke a conventional cigarette.
Aspects of the present description relate to formulations and devices for inducing a biological effect linked to nicotine (for example, a stimulating effect of nicotine) in a user. In embodiments, the biological effect related to nicotine (for example, a nicotine stimulating effect) is comparable to that of a conventional cigarette such as a Pall Mall® or Newport 100® cigarette. In embodiments the conventional cigarette is the type of cigarette preferred by the user. A "nicotine-related biological effect" is an effect that is detectable by the user (for example, a subject) and includes, but is not limited to, a stimulating effect (also referred to herein as the nicotine stimulating effect) or a relaxing effect (for example, reduced anxiety or irritability). In embodiments, the biological effect related to nicotine is a stimulating effect (also referred to herein as the stimulating effect of nicotine). In embodiments, a biological effect related to nicotine is improved concentration. In embodiments, a biological effect linked to nicotine is increased alertness. A stimulating effect of nicotine can be manifested by, for example, an increase in heart rate, an increase in blood pressure, and / or a feeling of satisfaction (for example, physical satisfaction or emotional satisfaction) of a user. In embodiments, an increased nicotine-related biological effect (e.g., a nicotine-stimulating effect, such as a faster rise in heart rate) can be achieved, for example, in about 10 seconds, approximately 20 seconds, approximately 40 seconds, approximately 60 seconds, approximately 80 seconds, approximately 100 seconds, approximately 120 seconds, approximately 140 seconds, approximately 160 seconds, approximately 180 seconds, approximately 200 seconds, approximately 220 seconds, approximately 240 seconds, approximately 260 seconds, approximately 280 seconds, approximately 300 seconds, approximately 320 seconds, approximately 340 seconds, approximately 360 seconds, approximately 7 minutes, approximately 8 minutes, approximately 9 minutes or approximately 10 minutes after administration of nicotine or protonated nicotine depending on the teachings of this description. In embodiments, the stimulating effect of nicotine is an increase in the heart rate. The increase in heart rate can be achieved, for example, in approximately 10 seconds, approximately 20 seconds, approximately 40 seconds, approximately 60 seconds, approximately 80 seconds, approximately 100 seconds, approximately 120 seconds, approximately 140 seconds, approximately 160 seconds, approximately 180 seconds, approximately 200 seconds, approximately 220 seconds, approximately 240 seconds, approximately 260 seconds, approximately 280 seconds, approximately 300 seconds, approximately 320 seconds, approximately 340 seconds, approximately 360 seconds, approximately 7 minutes, approximately 8 minutes, approximately 9 minutes or about 10 minutes after the administration of nicotine or protonated nicotine according to the teachings of the present description. In embodiments, the effective amount of nicotine (e.g., protonated nicotine) raises a user's heart rate by about 10% or about 15% or about 20% or about 25% or about 30% or about 35 % or approximately 40% or approximately 45% or approximately 50% or approximately 55% or approximately 60% compared to the user's heart rate before administration of nicotine (for example, protonated nicotine) according to the teachings of the present description. In embodiments, the effective amount of protonated nicotine raises a user's heart rate by about 10% or about 15% or about 20% or about 25% or about 30% or about 35% or about 40% or about 45% or about 50% or about 55% or about 60% compared to the heart rate of a corresponding user who receives the same amount of nicotine as free base. In embodiments, the heart rate is the resting heart rate. In embodiments, the biological effect associated with nicotine is a reduced urge to smoke a cigarette. In embodiments, reduced urge is observed in about 10 seconds, about 20 seconds, about 40 seconds, about 60 seconds, about 80 seconds, about 100 seconds, about 120 seconds, about 140 seconds, about 160 seconds, about 180 seconds, approximately 200 seconds, approximately 220 seconds, approximately 240 seconds, approximately 260 seconds, approximately 280 seconds, approximately 300 seconds, approximately 320 seconds, approximately 340 seconds, approximately 360 seconds, approximately 7 minutes, approximately 8 minutes, approximately 9 minutes or approximately 10 minutes after the administration of nicotine or protonated nicotine according to the teachings of the present description. In embodiments, the biological effect related to nicotine is a pleasant sensation in the throat or chest. In embodiments, the biological effect related to nicotine is any combination of 2, 3, 4, 5, or more than 5, effects associated with nicotine presently described or known in the art. Such effects are not limited to what a user can perceive, and can therefore include both objective and subjective effects.
In embodiments, the use of a liquid nicotine formulation presently described mimics the peak of nicotine delivery of a conventional cigarette. In embodiments, the value (s) C _max and / or T _max for the plasma nicotine levels of a user are comparable to those of a conventional cigarette (or are close to those of a conventional cigarette , for example, are 90 to 100% or at least about 80%, 85%, 90% or 95% of the C _max and / or T _{max value} of the conventional cigarette). In embodiments, the rate of absorption of nicotine into the blood plasma of users is approximately the same as that of a conventional cigarette (for example, the C _max and T _max values are at least about 90% of the C _max and T _max values of a conventional cigarette). In embodiments, the rate of absorption of nicotine into the plasma or blood of users is lower than that of conventional cigarettes, but sufficient to, for example, reduce the urge for a conventional cigarette. In embodiments, formulations (e.g., nicotine-organic acid formulations) that exhibit the fastest rate of nicotine absorption in plasma are more preferred in satisfaction ratings, and are considered to be more equivalent to the satisfaction of a cigarette than the formulations with the slower rates of elevation of nicotine in the plasma. In embodiments, a user rates their level of satisfaction as at least 3 on a scale in the range of 1 to 7, where 1 = not at all satisfied, 2 = very little satisfied, 3 = somewhat satisfied, 4 = moderately satisfied, 5 = satisfied, 6 = very satisfied and 7 = extremely satisfied. In embodiments, the user assesses his level of satisfaction at 4 on the scale. In embodiments, the user assesses his level of satisfaction at 5 on the scale. In embodiments, the user assesses his level of satisfaction at 6 on the scale. In embodiments, the user assesses his level of satisfaction at 7 on the scale.
In one aspect, a liquid nicotine formulation comprising nicotine, an acid (such as an organic acid), and a liquid carrier is provided. In embodiments, upon heating the formulation, an inhalable aerosol is formed comprising an effective amount of nicotine and / or protonated nicotine. In embodiments, upon heating the formulation, an inhalable aerosol is formed comprising an effective amount of protonated nicotine. In embodiments, the formulation is in a cartridge. In embodiments, the cartridge is in an electronic nicotine delivery system. An "effective amount" of a compound (such as nicotine) is an amount sufficient for the compound to perform a specified function in relation to the absence of the compound (for example, to achieve the effect for which it is administered). The term "effective amount" further includes an amount which is more than sufficient to perform the intended function, provided that the intended function is fulfilled without excessive undesirable side effects (such as toxicity or irritation) in proportion to a benefit ratio / reasonable risk when used in accordance with the manner described in this description. In embodiments, an effective amount of nicotine (such as protonated nicotine, free base nicotine, or a combination thereof) is an amount of nicotine which is sufficient to lead to a biological effect related to nicotine ( for example, a stimulant effect of nicotine) in a user.
[0138] In one aspect, a method of providing nicotine to a user (also referred to herein as a subject) of an electronic nicotine delivery system is provided. "Loumir" of nicotine to a user includes the provision of nicotine (for example, through an electronic nicotine delivery system) or the administration of nicotine (for example, through 'an electronic nicotine delivery system) to a user. In embodiments, administration is self-administration. In embodiments, "providing" nicotine to a user may include providing, selling, and / or distributing to a user who wishes to self-administer nicotine from a device that is configured to be operated by the user. In embodiments, nicotine is self-administered by inhalation of an aerosol comprising nicotine, the nicotine being produced by the device when the device is actuated.
In embodiments, the method comprises (a) heating a liquid formulation of nicotine in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, the aerosol comprising protonated nicotine in an amount such that the user experiences a biological effect related to nicotine.
In embodiments, the method comprises (a) heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, the aerosol comprising the organic acid in an amount such that the user has little or no desire for a conventional cigarette.
In embodiments, the method comprises (a) heating a liquid formulation of nicotine in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, the aerosol comprising nicotine and an amount of organic acid sufficient to, after inhalation by a user, cause an increased nicotine-related biological effect. in the user compared to the absence of organic acid.
In embodiments, the method comprises (a) actuation (by the user) of an electronic nicotine delivery system as presently described comprising a liquid formulation of nicotine, the formulation comprising nicotine , an organic acid, and a liquid vehicle, the electronic nicotine delivery system heating the formulation to an operating temperature, so that an inhalable aerosol comprising an effective amount of protonated nicotine is produced; and (b) inhalation (by the user) of the inhalable aerosol. The operation of an electronic nicotine delivery system includes the activation of essential electronic components of the electronic nicotine delivery system to enable heating and inhalation. In embodiments, the operation of an electronic nicotine delivery system comprises, consists essentially of, or consists of the user holding the electronic nicotine delivery system and aspirating from a mouthpiece of the electronic system nicotine administration. In embodiments, the effective amount is an amount such that the user exhibits a biological effect related to nicotine after inhalation.
[0143] In embodiments, an effective amount of nicotine is effective in reducing the urge of a user for a conventional cigarette. In some embodiments, the urge is completely reduced so that the user has no desire for conventional cigarettes. In embodiments, the biological effect related to nicotine is a physiological response that is similar to or equivalent to the response to nicotine produced by smoking a conventional cigarette. In embodiments, the biological effect related to nicotine is the stimulation of nicotine which mimics (for example, is equivalent to) that of a conventional cigarette. In embodiments, the biological effect related to nicotine is an increased heart rate which mimics the increased heart rate of a user who smokes a conventional cigarette. The heart rate of a user who smokes a conventional cigarette can now be called the "heart rate of a conventional cigarette". An increased heart rate "mimics" that of a conventional cigarette if the heart rate is approximately the same as, has approximately the same amplitude as, or has approximately the same rate of increase as the heart rate of a conventional cigarette.
In embodiments, the method comprises (a) heating a liquid formulation of nicotine in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, in which the organic acid is present in an amount such that the user has little or no desire for a conventional cigarette.
In embodiments, the method comprises (a) heating a liquid formulation of nicotine in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, in which the organic acid is present in an amount such that the user exhibits a physiological response which is similar or equivalent to the response to nicotine produced by smoking. a conventional cigarette.
In embodiments, the method comprises (a) heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, in which the organic acid is present in an amount such that the user exhibits an increased nicotine-related biological effect (for example, a faster rise in heart rate) which mimics that of a conventional cigarette.
In embodiments, the method comprises (a) heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user, the organic acid being present in an amount sufficient to produce stimulation of nicotine which mimics that of a conventional cigarette.
In embodiments, the aerosol comprises sufficient protonated nicotine to, after inhalation by a user, cause an increase in the plasma nicotine level in the user who imitates a conventional cigarette.
In embodiments, the method comprises (a) heating a liquid formulation of nicotine in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and acid benzoic in a liquid vehicle, the formulation comprising an amount of protonated nicotine from about 0.5% to about 5% or from about 1.5% to about 2.5%; and (b) user inhalation of the aerosol. In embodiments, most or all of the nicotine is protonated in the formulation. In embodiments, at least 85 to 95%, 85 to 90%, 85 to 99%, 90 to 95%, 90 to 99% or 95 to 99% of the nicotine in the formulation is protonated. In embodiments, at least about 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the nicotine is protonated. In embodiments, from about 85%, 86%, 87%, 88%, 89% or 90% to about 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98 % or 99% of nicotine is protonated. In embodiments, 100% of the nicotine is protonated. In embodiments, at least 85% of the nicotine is protonated. In embodiments, at least 90% of the nicotine is protonated. In embodiments, at least 91% of the nicotine is protonated. In embodiments, at least 92% of the nicotine is protonated. In embodiments, at least 93% of the nicotine is protonated. In embodiments, at least 94% of the nicotine is protonated. In embodiments, at least 95% of the nicotine is protonated. In embodiments, at least 96% of the nicotine is protonated. In embodiments, at least 97% of the nicotine is protonated. In embodiments, at least 98% of the nicotine is protonated. In embodiments, at least 99% of the nicotine is protonated.
In embodiments, a greater amount or all of the nicotine in an aerosol product (for example, in a device, or according to a method described herein) is protonated. In embodiments, at least 85 to 95%, 85 to 90%, 85 to 99%, 90 to 95%, 90 to 99% or 95 to 99% of the nicotine in the aerosol is protonated. In embodiments, at least about 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the nicotine is protonated. In embodiments, from about 85%, 86%, 87%, 88%, 89% or 90% to about 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98 % or 99% of nicotine is protonated. In embodiments, 100% of the nicotine is protonated. In embodiments, at least 85% of the nicotine is protonated. In embodiments, at least 90% of the nicotine is protonated. In embodiments, at least 91% of the nicotine is protonated. In embodiments, at least 92% of the nicotine is protonated. In embodiments, at least 93% of the nicotine is protonated. In embodiments, at least 94% of the nicotine is protonated. In embodiments, at least 95% of the nicotine is protonated. In embodiments, at least 96% of the nicotine is protonated. In embodiments, at least 97% of the nicotine is protonated. In embodiments, at least 98% of the nicotine is protonated. In embodiments, at least 99% of the nicotine is protonated.
In embodiments, the method includes (a) heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and acid benzoic in a liquid vehicle; and (b) user inhalation of the aerosol.
In embodiments, the method comprises (a) heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and acid lactic acid in a liquid vehicle; and (b) user inhalation of the aerosol.
In embodiments, the method comprises (a) heating a liquid formulation of nicotine in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine, acid benzoic and lactic acid in a liquid vehicle; and (b) inhalation of the aerosol by the user.
[0154] In one aspect, a method of producing an inhalable aerosol comprising nicotine and benzoic acid is provided. In embodiments, the method includes heating nicotine and benzoic acid in an electronic inhaler to produce the aerosol, the aerosol comprising nicotine and an amount of benzoic acid sufficient to, after inhalation by a user , cause an increased biological effect of nicotine (for example, a faster rise in heart rate) in the user compared to the absence of benzoic acid. In one aspect, a method of producing an inhalable aerosol comprising nicotine and lactic acid is provided. In embodiments, the method includes heating nicotine and lactic acid in an electronic inhaler to produce the aerosol, the aerosol comprising nicotine and an amount of lactic acid sufficient to, after inhalation by a user , cause an increased nicotine-related biological effect (for example, a faster rise in heart rate) in the user compared to the absence of lactic acid. In one aspect, a method of producing an inhalable aerosol comprising nicotine, benzoic acid and lactic acid is provided. In embodiments, the method includes heating nicotine, benzoic acid and lactic acid in an electronic inhaler to produce the aerosol, the aerosol comprising nicotine and an amount of benzoic acid and sufficient lactic acid to cause increased nicotine-related biological effect (eg, faster heart rate increase) in the user after inhalation by a user compared to the absence of benzoic acid and l 'Lactic acid.
In embodiments, the method comprises heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and one or more organic acids in a liquid vehicle, the one or more organic acids comprising a keto acid, an aliphatic monocarboxylic acid, an aliphatic dicarboxylic acid, an aromatic acid and / or a hydroxy acid.
In embodiments, the method includes heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and a carboxylic acid in a liquid vehicle , the carboxylic acid being a beta-keto acid, an aliphatic monocarboxylic acid, an aliphatic dicarboxylic acid, an aromatic acid or a hydroxy acid. In embodiments, the formulation comprises an amount of the carboxylic acid sufficient to, after inhalation, cause an increased nicotine-related biological effect (e.g., faster rise in heart rate) in the user by compared to the absence of the carboxylic acid. In embodiments, the formulation comprises an amount of the carboxylic acid sufficient to, after inhalation, cause a faster rise in heart rate in the user compared to the absence of the carboxylic acid.
In embodiments, the method includes heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle , where (a) the formulation includes an amount of organic acid sufficient to cause an increased nicotine-related biological effect after inhalation (e.g., faster rise in heart rate) in the user compared to absence of organic acid; and (b) the electronic nicotine delivery system includes a cartridge, the cartridge serving as a reservoir which contains the formulation and a mouthpiece for the electronic nicotine delivery system.
In embodiments, the method includes heating a liquid nicotine formulation in an electronic nicotine delivery system to produce an inhalable aerosol, the formulation comprising nicotine and an organic acid in a liquid vehicle , where (a) the pH of the liquid formulation is sufficiently acidic to, after inhalation, cause an increased nicotine-related biological effect (e.g., faster rise in heart rate) in the user compared to the absence organic acid; and (b) the electronic nicotine delivery system includes a cartridge, the cartridge serving as a reservoir which contains the formulation and a mouthpiece for the electronic nicotine delivery system. In embodiments, the pH of the formulation is less than 7.0. In embodiments, the pH of the formulation is about
2.5 to about 6.5. In embodiments, the pH of the formulation is from about 3 to about 6.5. In embodiments, the pH of the formulation is from about 4 to about 6.5. In embodiments, the pH of the formulation is from about 5 to about 6.5. In embodiments, the pH of the formulation is from about 6 to about 6.5. In embodiments, the pH of the formulation is from about 3 to about 5.5. In embodiments, the pH of the formulation is from about 3.5 to about 5.5. In embodiments, the pH of the formulation is about 2.5, 3,
3.5.4, 4.5, 5, 5.5, 6 or 6.5.
In embodiments, the aerosol comprises a protonated nicotine level such that the user has approximately 80 to 100% or at least approximately 80%, 85%, 86%, 87%, 88%, 89% , 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the C _max value of plasma nicotine in a conventional cigarette. In embodiments, the aerosol includes a level of protonated nicotine such that the user has about 80 to 100% or at least about 80%, 85%, 86%, 87%, 88%, 89%, 90% , 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the T _max value of plasma nicotine in a conventional cigarette.
In embodiments, the aerosol comprises an amount of nicotine in combination with an organic acid such that the user has approximately 80 to 100% or at least approximately 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the C _max value of plasma nicotine in a conventional cigarette. In embodiments, the aerosol comprises an amount of nicotine in combination with an organic acid such that the user has about 80 to 100% or at least about 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% of the T _max value of plasma nicotine in a conventional cigarette.
In one aspect, a device (for example, an electronic nicotine delivery system such as an electronic nicotine delivery system presently described) comprising a liquid nicotine formulation currently described is provided.
In one aspect, an electronic nicotine delivery system cartridge comprising a liquid nicotine formulation presently described is provided. In embodiments, the cartridge is in a package such as a blister. In embodiments, the cartridge is in an electronic nicotine delivery system. In embodiments, the cartridge serves as a mouthpiece and a reservoir for formulation. In embodiments, the cartridge is a cartomizer.
In embodiments, the aerosol produced from an electronic nicotine delivery system is produced from a single nicotine liquid formulation which is in a single reservoir contained in an electronic delivery system. nicotine administration or a cartridge thereof.
Non-limiting examples of liquid nicotine formulations comprising one or more organic acids are described in U.S. Patent Ri 9,215,895; U.S. ri patent application publication 2016/0302471; and the PCT ri international application publication WO 2018/031600, the entire content of each of which is currently incorporated by reference.
Unless otherwise indicated and depending on the context, the term “nicotine” denotes “free base nicotine and / or protonated nicotine” (independently of the counterion). In embodiments, the nicotine in a liquid nicotine formulation presently described is naturally occurring nicotine (e.g., derived from extracts of nicotinic species such as tobacco), or synthetic nicotine. In embodiments, nicotine is (-) - nicotine, (+) - nicotine, or a mixture thereof. In embodiments, nicotine is used in relatively pure form (e.g., more than about 80%, 85%, 90%, 95%, 99% pure,
99.5% or 99.9% by weight before being combined with one or more other components of a formulation). In some embodiments, the nicotine for a formulation presently described is "clear" in appearance in order to avoid or minimize the formation of tarry residues during the subsequent formulation steps. In embodiments, 90 to 100% or at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99.1%, 99, 2%, 99.3%, 99.4%,
99.5%, 99.6%, 99.7%, 99.8% or 99.9% of the nicotine in a formulation is (-) - nicotine.
In embodiments, a liquid formulation of nicotine comprises an organic acid.
The term “organic acid” designates an organic compound having acidic properties (for example, according to the definition of Brpnsted-Lowry, or the definition of Lewis). Common organic acids are carboxylic acids, the acidity of which is associated with their carboxyl group (-COOH). A dicarboxylic acid has two carboxylic acid groups. The relative acidity of an organic substance is measured by its pK _a and the skilled person knows how to determine the acidity of an organic acid on the basis of its pK _a value given. The term "keto acid" in the present context means organic compounds which contain a carboxylic acid group and a ketone group. Common types of keto acids include alpha-keto acids, or 2-oxo acids, such as pyruvic acid or oxaloacetic acid, having the keto group adjacent to the carboxylic acid; beta-keto acids, or 3-oxo acids, such as acetoacetic acid, having the ketone group at the second carbon from the carboxylic acid; and gamma-keto acids, or 4-oxo acids, such as levulinic acid, having the ketone group at the third carbon from the carboxylic acid. In embodiments, the organic acid is benzoic acid, oxalic acid, salicylic acid, succinic acid, sorbic acid, pyruvic acid, levulinic acid, or acid lactic.
[0168] In embodiments, the organic acid is a carboxylic acid. In embodiments, the carboxylic acid is an aliphatic acid. In embodiments, the aliphatic acid is a straight chain aliphatic acid. In embodiments, the aliphatic acid is a branched chain aliphatic acid. In embodiments, the aliphatic acid is an aliphatic monocarboxylic acid. In embodiments, the aliphatic acid is an aliphatic dicarboxylic acid. In embodiments, the aliphatic dicarboxylic acid is malonic acid or succinic acid. In embodiments, the carboxylic acid is an aromatic acid. In embodiments, the aromatic acid is benzoic acid or phenylacetic acid.
[0169] In embodiments, the carboxylic acid is a hydroxy acid. In embodiments, the hydroxy acid is lactic acid.
[0170] In embodiments, the organic acid is a keto acid. In embodiments, the keto acid is an alpha-keto acid. In embodiments, the alpha-keto acid is pyruvic acid or oxaloacetic acid. In embodiments, the keto acid is a beta keto acid. In embodiments, the beta-keto acid is acetoacetic acid. In embodiments, the keto acid is a gamma-keto acid. In embodiments, the gamma-keto acid is levulinic acid.
In embodiments, the organic acid is any one or more of 2-furoic acid, acetic acid, acetoacetic acid, alphamethylbutyric acid, ascorbic acid, benzoic acid, beta-methylvaleric acid, butyric acid, caproic acid, citric acid, formic acid, fumaric acid, glycolic acid, heptanoic acid, isobutyric acid, isovaleric acid, lactic acid, levulinic acid, malic acid, malonic acid, myristic acid, nonanoic acid, octanoic acid, oxalic acid, oxaloacetic acid , phenylacetic acid, pro pionic acid, pyruvic acid, succinic acid and tartaric acid.
Nonlimiting examples of organic acids include aromatic acids such as optionally substituted benzoic acids, hydroxy acids, heterocyclic acids, terpenoids, sugar acids such as pectic acids, amino acids, acids cycloaliphatics, dicarboxylic acids, aliphatic acids, keto acids, and the like. In embodiments, a formulation comprises one or more organic acids which are aliphatic acids (e.g., straight chain and / or branched chain aliphatic acids). In embodiments, a formulation comprises one or more organic acids which are aliphatic monocarboxylic acids such as acetic acid, propionic acid, isobutyric acid, butyric acid, or the like. In embodiments, a formulation comprises one or more organic acids which are ketocarboxylic acids. In embodiments, a formulation includes formic, acetic, propionic, isobutyric, butyric, alpha-methylbutyric, isovaleric, beta-methylvaleric, caproic, 2-furoic, phenylacetic, heptanoic, octanoic, nonanoic, malic, citric acid. , oxalic, malonic, glycolic, succinic, ascorbic, tartaric, fumaric and / or pyruvic. In embodiments, a formulation comprises one or more C ₄ to C ₂ s fatty acids, and other acids.
In embodiments, a formulation comprises one or more carboxylic acids. Nonlimiting examples of carboxylic acids include monocarboxylic acids, dicarboxylic acids (organic acid containing two carboxylic acid groups), and carboxylic acids containing an aromatic group such as benzoic acids, hydroxycarboxylic acids, heterocyclic carboxylic acids, terpenoids, sugar acids such as pectic acids, amino acids, cycloaliphatic acids, aliphatic carboxylic acids, ketocarboxylic acids, and the like. In embodiments, a formulation comprises one or more of formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, acid palmitic, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, gluconic acid, saccharic acid, salicyclic acid, sorbic acid, malonic acid and malic acid. In embodiments, a formulation comprises one or more of benzoic acid, pyruvic acid, salicylic acid, levulinic acid, malic acid, succinic acid and citric acid. In embodiments, a formulation comprises one or more of benzoic acid, pyruvic acid and salicylic acid. In embodiments, a formulation comprises benzoic acid. In embodiments, a formulation comprises lactic acid. In embodiments, a formulation comprises benzoic acid and lactic acid. In embodiments, a formulation comprises at least one of benzoic acid, oxalic acid, salicylic acid, succinic acid, sorbic acid, pyruvic acid, levulinic acid or lactic acid.
[0174] In embodiments, an organic acid used in a liquid nicotine formulation does not decompose at the operating temperature of the electronic nicotine delivery system.
In embodiments, the formulation does not include citric acid. In embodiments, the formulation does not include pyruvic acid. In embodiments, the formulation does not include malic acid. In embodiments, the formulation does not include more than 10, 9, 8, 7, 6, 5, 4, 3, 2 or 1 acid (s). In embodiments, the formulation does not include more than 10, 9, 8, 7, 6, 5, 4, 3, 2 or 1 organic acid (s). In embodiments, the formulation does not include more than 10 organic acids. In embodiments, the formulation does not include more than 9 organic acids. In embodiments, the formulation does not include more than 8 organic acids. In embodiments, the formulation does not include more than 7 organic acids. In embodiments, the formulation does not include more than 6 organic acids. In embodiments, the formulation does not include more than 5 organic acids. In embodiments, the formulation does not include more than 4 organic acids. In embodiments, the formulation does not include more than 3 organic acids. In embodiments, the formulation does not include more than 2 organic acids. In embodiments, the formulation does not include more than 1 organic acid. In embodiments, the formulation does not include more than 10 carboxylic acids. In embodiments, the formulation does not include more than 9 carboxylic acids. In embodiments, the formulation does not include more than 8 carboxylic acids. In embodiments, the formulation does not include more than 7 carboxylic acids. In embodiments, the formulation does not include more than 6 carboxylic acids. In embodiments, the formulation does not include more than 5 carboxylic acids. In embodiments, the formulation does not include more than 4 carboxylic acids. In embodiments, the formulation does not include more than 3 carboxylic acids. In embodiments, the formulation does not include more than 2 carboxylic acids. In embodiments, the formulation comprises 1 single carboxylic acid.
In embodiments, a formulation comprises an organic compound which has an acidic character and is capable of forming a counterion with nicotine when it is in its conjugated base form. Exemplary compounds include phenolics such as guaiacol, vanillin, protocatechualdehyde, and the like.
In embodiments, the concentration of nicotine in the liquid nicotine formulation is from approximately 0.5% to approximately 25%, the concentration being by weight of nicotine relative to the total weight of solution, this is i.e. (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 20% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 18% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 15% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 4% (m / m) to about 12% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about% (m / m) to about 18% (m / m), about 3% (m / m) to about 15% (m / m) or about 4% (m / m) to about 12% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about 10% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about 5% (m / m).
In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about 4% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about 3% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about 1% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 10% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 4% (m / m).
In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 3% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 2% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 2% (m / m) to about 10% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 2% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 2% (m / m) to about 4% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of about 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1 , 1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2 , 1%,
2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%,
3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.5%, 5.0%, 5.5%, 6.0%, 6.5%,
7.0%, 7.5%, 8.0%, 8.5%, 9.0%, 9.5%, 10%, 11%, 12%, 13%, 14%, 15%, 16% ,%, 18%, 19% or 20% (m / m), or more, including any increments therebetween. In embodiments, a liquid nicotine formulation includes a liquid nicotine formulation having a nicotine concentration of approximately 5% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of about 4% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of about% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of about 2% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of about 1% (m / m).
In embodiments, a liquid nicotine formulation has a nicotine concentration of about 0.5% (m / m).
In embodiments, a liquid nicotine formulation has a nicotine concentration of about 0.5% (m / m), 1% (m / m), about 2% (m / m), about 3% (m / m), about 4% (m / m), about 5% (m / m), about 6% (m / m), about 7% (m / m), about 8% (m / m), about 9% (m / m), about 10% (m / m), about 11% (m / m), about 12% (m / m), about 13% (m / m), about 14 % (m / m), about 15% (m / m), about 16% (m / m), about 17% (m / m), about 18% (m / m), about 19% (m / m ) or about 20% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 0.5% (m / m) to about 20% (m / m), from about 0.5% (m / m) about 18% (m / m), about 0.5% (m / m) about 15% (m / m), about 0.5% (m / m) to about 12% (m / m), from about 0.5% (m / m) to about 10% (m / m), from about 0.5% (m / m) to about 8% (m / m), about 0.5% (m / m) to about 7% (m / m), about 0.5% (m / m) to about 6% (m / m), about 0.5% ( m / m) to about 5% (m / m), from about 0.5% (m / m) to about% (m / m), from about 0.5% (m / m) to about 3 % (m / m), or from about 0.5% (m / m) to about 2% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 1% (m / m) to about 20% (m / m), from about 1% (m / m) to about 18% (m / m), from about 1% (m / m) to about 15% (m / m), from about 1% (m / m) to about 12% (m / m), from about 1 % (m / m) to about 10% (m / m), from about 1% (m / m) to about 8% (m / m), from about 1% (m / m) to about 7% (m / m), from about 1% (m / m) to about 6% (m / m), from about 1% (m / m) to about 5% (m / m), from about 1 % (m / m) to about 4% (m / m), from about 1% (m / m) to about 3% (m / m), or from about 1% (m / m) to about 2 % (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 2% (m / m) to about 20% (m / m), from about 2% (m / m) to about 18% (m / m), from about% (m / m) to about 15% (m / m), from about 2% (m / m) to about 12% (m / m), from about 2% (m / m) to about 10% (m / m), from about 2% (m / m) to about 8% (m / m), from about 2% (m / m) to about 7% ( m / m), from about 2% (m / m) to about 6% (m / m), from about 2% (m / m) to about 5% (m / m), from about 2% (m / m) to about 4% (m / m), or from about 2% (m / m) to about 3% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 3% (m / m) to about 20% (m / m), from about 3% (m / m) to about 18% (m / m), from about% (m / m) to about 15% (m / m), from about 3% (m / m) to about 12% (m / m), from about 3% (m / m) to about 10% (m / m), from about 3% (m / m) to about 8% (m / m), from about 3% (m / m) to about 7% ( m / m), about 3% (m / m) to about 6% (m / m), about 3% (m / m) to about 5% (m / m), or about 3 % (m / m) to about% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 4% (m / m) to about 20% (m / m), from about 4% (m / m) to about 18% (m / m), from about 4% (m / m) to about 15% (m / m), from about% (m / m) to about 12% (m / m), from about 4% (m / m) to about 10% (m / m), from about 4% (m / m) to about 8% (m / m), from about 4% (m / m) to about 7% ( m / m), from about 4% (m / m) to about 6% (m / m), or from about 4% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 5% (m / m) to about 20% (m / m), from about 5% (m / m) to about 18% (m / m), from about 5% (m / m) to about 15% (m / m), from about% (m / m) to about 12% (m / m), from about 5% (m / m) to about 10% (m / m), from about 5% (m / m) to about 8% (m / m), from about 5% (m / m) to about 7% ( m / m), or from about 5% (m / m) to about 6% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 6% (m / m) to about 20% (m / m), from about 6% (m / m) to about 18% (m / m), from about 6% (m / m) to about 15% (m / m), from about 6% (m / m) to about 12% (m / m), from about% (m / m) to about 10% (m / m), from about 6% (m / m) to about 8% (m / m), or from about 6% (m / m) to about 7% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of from about 2% (m / m) to about 6% (m / m). In embodiments, a liquid nicotine formulation has a nicotine concentration of about 5% (m / m).
In embodiments, the concentration of nicotine in the liquid nicotine formulation is approximately 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5% , 1.6% or 1.7% to about 2.5%, 2.4%, 2.3%, 2.2%, 2.1%, 2.0%, 1.9% or 1.8 % (m / m).
In embodiments, the concentration of nicotine in the liquid nicotine formulation is about 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1, 6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4% or 2.5% (m / m).
In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is from about 0.5% (m / m) to about 25% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is from about 1% (m / m) to about 20% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is from about 1% (m / m) to about 18% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is from about 1% (m / m) to about 15% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is from about 4% (m / m) to about 12% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is from about 2% (m / m) to about 6% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is about 5% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is about 4% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is approximately 3% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is about 2% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is about 1% (m / m).
In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is approximately 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5 %, 1.6% or 1.7% to about 2.5%, 2.4%, 2.3%, 2.2%, 2.1%, 2.0%, 1.9% or 1, 8% (m / m). In embodiments, the concentration of protonated nicotine in the liquid nicotine formulation is about 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1 , 6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4% or 2.5% (m / m).
In embodiments, the concentration of organic acid in the liquid nicotine formulation is from approximately 0.5% to approximately 25%, the concentration being by weight of organic acid relative to the total weight of solution , i.e. (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 20% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 18% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 15% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 4% (m / m) to about 12% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 18% (m / m), about 3% (m / m) to about 15% (m / m) or about 4% (m / m) to about 12% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 10% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 4% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 3% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 2% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 1% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 10% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 4% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 3% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 2% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 2% (m / m) to about 10% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 2% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 2% (m / m) to about 4% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% , 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0% , 2.1%, 2.2%, 2.3%, 2.4%,
2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3, 5%, 3.6%,
3.7%, 3.8%, 3.9%, 4.0%, 4.5%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 7.5%, 8.0%,
8.5%, 9.0%, 9.5%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19% or 20% (m / m) , or more, including any increments therein. In embodiments, a liquid nicotine formulation comprises a liquid nicotine formulation having an organic acid concentration of about 5% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 4% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 3% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 2% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 1% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 0.5% (m / m).
In embodiments, a liquid nicotine formulation has an organic acid concentration of about 0.5% (m / m), 1% (m / m), about 2% (m / m) , about 3% (m / m), about 4% (m / m), about 5% (m / m), about 6% (m / m), about 7% (m / m), about 8% ( m / m), about 9% (m / m), about 10% (m / m), about 11% (m / m), about 12% (m / m), about 13% (m / m), about 14% (m / m), about 15% (m / m), about 16% (m / m), about 17% (m / m), about 18% (m / m), about 19% (m / m) or about 20% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 0.5% (m / m) to about 20% (m / m), from about 0.5% (m / m) to about 18% (m / m), from about 0.5% (m / m) to about 15% (m / m), from about 0.5% (m / m) to about 12% (m / m), from about 0.5% (m / m) to about 10% (m / m), from about 0.5% (m / m) to about 8% (m / m), from about 0.5% (m / m) to about 7% (m / m), from about 0.5% (m / m) to about 6% (m / m), from about 0.5 % (m / m) to about 5% (m / m), from about 0.5% (m / m) to about 4% (m / m), from about 0.5% (m / m) about 3% (m / m), or about 0.5% (m / m) to about 2% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 1% (m / m) to about 20% (m / m), from about 1% (m / m) to about 18% (m / m), from about% (m / m) to about 15% (m / m), from about 1% (m / m) to about 12% (m / m), from about 1% (m / m) to about 10% (m / m), from about 1% (m / m) to about 8% (m / m), from about 1% (m / m) to about 7 % (m / m), from about 1% (m / m) to about 6% (m / m), from about 1% (m / m) to about 5% (m / m), from about 1% (m / m) to approximately 4% (m / m), approximately 1% (m / m) to approximately 3% (m / m), or approximately 1% (m / m) to approximately % (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 2% (m / m) to about 20% (m / m), from about 2% (m / m) to about 18% (m / m), from about 2% (m / m) to about 15% (m / m), from about 2% (m / m) to about 12% (m / m), of approximately 2% (m / m) to approximately 10% (m / m), approximately 2% (m / m) to approximately 8% (m / m), approximately 2% (m / m) to approximately 7% (m / m), from about 2% (m / m) to about 6% (m / m), from about 2% (m / m) to about 5% (m / m), about 2% (m / m) to about 4% (m / m), or about 2% (m / m) to about 3% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 3% (m / m) to about 20% (m / m), from about 3% (m / m) to about 18% (m / m), from about 3% (m / m) to about 15% (m / m), from about 3% (m / m) to about 12% (m / m), of about 3% (m / m) to about 10% (m / m), about 3% (m / m) to about 8% (m / m), about 3% (m / m) to about 7% (m / m), from about 3% (m / m) to about 6% (m / m), from about 3% (m / m) to about 5% (m / m), or d '' about 3% (m / m) to about 4% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 4% (m / m) to about 20% (m / m), from about 4% (m / m) to about 18% (m / m), from about 4% (m / m) to about 15% (m / m), from about 4% (m / m) to about 12% (m / m), of about 4% (m / m) to about 10% (m / m), about 4% (m / m) to about 8% (m / m), about 4% (m / m) to about 7% (m / m), from about 4% (m / m) to about 6% (m / m), or from about 4% (m / m) to about 5% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 5% (m / m) to about 20% (m / m), from about 5% (m / m) to about 18% (m / m), from about 5% (m / m) to about 15% (m / m), from about 5% (m / m) to about 12% (m / m), about 5% (m / m) to about 10% (m / m), about 5% (m / m) to about 8% (m / m), about 5% (m / m) to about 7% (m / m), or from about% (m / m) to about 6% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 6% (m / m) to about 20% (m / m), from about 6% (m / m) to about 18% (m / m), from about 6% (m / m) to about 15% (m / m), from about 6% (m / m) to about 12% (m / m), of about% (m / m) to about 10% (m / m), about 6% (m / m) to about 8% (m / m), or about 6% (m / m) to about 7% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of from about 2% (m / m) to about 6% (m / m). In embodiments, a liquid nicotine formulation has an organic acid concentration of about 5% (m / m).
In embodiments, the concentration of organic acid in the liquid nicotine formulation is approximately 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1, 5%,
1.6% or 1.7% to about 2.5%, 2.4%, 2.3%, 2.2%, 2.1%, 2.0%, 1.9% or 1.8% (m / m). In embodiments, the concentration of organic acid in the liquid nicotine formulation is about 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%,
1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4% or 2.5% ( m / m).
Unless otherwise indicated with regard to nicotine concentrations (for example, total nicotine, free base nicotine, and / or protonated nicotine) in a liquid nicotine formulation, the term "approximately", in the context of a numerical value or range, means ± 10% of the numerical value or range mentioned or claimed, unless the context requires a more limited range. In each case in which a numeric value or range is preceded by the term "approximately" in this description, the specific numeric value or range without the term "approximately" is also described. For example, a disclosure of "approximately 1%" is also a disclosure of "1%". When a numeric range is provided, all integers in that range, and tenths of them, are also described. For example, "0.5% to 5%" is a disclosure of 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, etc. ., up to and including 5%.
In embodiments, the pH of the liquid nicotine formulation is less than 7.0. In embodiments, the pH of the formulation is from about 2.5 to about 6.5. In embodiments, the pH of the formulation is from about 3 to about 6.5. In embodiments, the pH of the formulation is from about 4 to about 6.5. In embodiments, the pH of the formulation is from about 5 to about 6.5. In embodiments, the pH of the formulation is from about 6 to about 6.5. In embodiments, the pH of the formulation is from about 3 to about 5.5. In embodiments, the pH of the formulation is from about 3.5 to about 5.5. In embodiments, the pH of the formulation is about 2.5, 3,
3.5.4, 4.5, 5, 5.5, 6 or 6.5.
In embodiments, a formulation may include different stoichiometric ratios and / or molar ratios of acid to nicotine, acid functional groups to nicotine, and hydrogens of acid functional group to nicotine. In embodiments, the molar ratio of nicotine to acid (nicotine: acid) is 1: 1, 1: 2, 1: 3, 1: 4, 2: 3, 2: 5, 2: 7, 3: 4, 3: 5, 3: 7, 3: 8, 3:10, 3:11, 4: 5, 4: 7, 4: 9, 4:10, 4:11, 4:13, 4: 14, 4:15, 5: 6, 5: 7, 5: 8, 5: 9, 5:11, 5:12, 5:13, 5:14, 5:16, 5:17, 5:18 or 5:19. In embodiments, the molar ratio of acid to nicotine (acidemicotine) is 1: 1, 1: 2, 1: 3, 1: 4, 2: 3, 2: 5, 2: 7, 3: 4, 3: 5, 3: 7, 3: 8, 3:10, 3:11, 4: 5, 4: 7, 4: 9, 4:10, 4:11, 4:13, 4:14, 4:15, 5: 6, 5: 7, 5: 8, 5: 9, 5:11, 5:12, 5:13, 5:14, 5:16, 5:17, 5:18 or 5: 19. In embodiments, the ratio is the ratio of nicotine to an acid in a formulation. In embodiments, the ratio is the ratio of nicotine to all acids in a formulation. In embodiments, the ratio is the ratio of nicotine to all organic acids in a formulation. In embodiments, the molar ratio of nicotine to acid in the formulation is 1: 1, 1: 2, 1: 3 or 1: 4. In embodiments, the molar ratio of acid to nicotine in the formulation is about 0.25: 1, about 0.3: 1, about 0.4: 1, about 0.5: 1, about 0 , 6: 1, approximately 0.7: 1, approximately 0.8: 1, approximately 0.9: 1, approximately 1: 1, approximately 1.2: 1, approximately 1.4: 1, approximately 1.6: 1, approximately 1.8: 1, approximately 2: 1, approximately 2.2: 1, approximately 2.4: 1, approximately 2.6: 1, approximately 2.8: 1, approximately 3: 1, approximately 3, 2: 1, approximately 3.4: 1, approximately 3.6: 1, approximately 3.8: 1 or approximately 4: 1. In embodiments, the molar ratio of acidic functional groups to nicotine in the formulation is about 0.25: 1, about 0.3: 1, about 0.4: 1, about 0.5: 1, about 0 , 6: 1, approximately 0.7: 1, approximately 0.8: 1, approximately 0.9: 1, approximately 1: 1, approximately 1.2: 1, approximately 1.4: 1, approximately 1.6: 1, approximately 1.8: 1, approximately 2: 1, approximately 2.2: 1, approximately 2.4: 1, approximately 2.6: 1, approximately 2.8: 1, approximately 3: 1, approximately 3, 2: 1, approximately 3.4: 1, approximately 3.6: 1, approximately 3.8: 1 or approximately 4: 1. In embodiments, the molar ratio of hydrogens of acidic functional group to nicotine in the formulation is about 0.25: 1, about 0.3: 1, about 0.4: 1, about 0.5: 1, approximately 0.6: 1, approximately 0.7: 1, approximately 0.8: 1, approximately 0.9: 1, approximately 1: 1, approximately 1.2: 1, approximately 1.4: 1, approximately 1, 6: 1, approximately 1.8: 1, approximately 2: 1, approximately 2.2: 1, approximately 2.4: 1, approximately 2.6: 1, approximately 2.8: 1, approximately 3: 1, approximately 3.2: 1, approximately 3.4: 1, approximately 3.6: 1, approximately 3.8: 1 or approximately 4: 1. In embodiments, the molar ratio of acid to nicotine in the aerosol is about 0.25: 1, about 0.3: 1, about 0.4: 1, about 0.5: 1, about 0.6: 1, approximately 0.7: 1, approximately 0.8: 1, approximately 0.9: 1, approximately 1: 1, approximately 1.2: 1, approximately 1.4: 1, approximately 1.6 : 1, approximately 1.8: 1, approximately 2: 1, approximately 2.2: 1, approximately 2.4: 1, approximately 2.6: 1, approximately 2.8: 1, approximately 3: 1, approximately 3 , 2: 1, approximately 3.4: 1, approximately 3.6: 1, approximately 3.8: 1 or approximately 4: 1. In embodiments, the molar ratio of acidic functional groups to nicotine in the aerosol is about 0.25: 1, about 0.3: 1, about 0.4: 1, about 0.5: 1, about 0.6: 1, approximately 0.7: 1, approximately 0.8: 1, approximately 0.9: 1, approximately 1: 1, approximately 1.2: 1, approximately 1.4: 1, approximately 1.6 : 1, approximately 1.8: 1, approximately 2: 1, approximately 2.2: 1, approximately 2.4: 1, approximately 2.6: 1, approximately 2.8: 1, approximately 3: 1, approximately 3 , 2: 1, approximately 3.4: 1, approximately 3.6: 1, approximately 3.8: 1 or approximately 4: 1. In embodiments, the molar ratio of hydrogens of acidic functional group to nicotine in the aerosol is about 0.25: 1, about 0.3: 1, about 0.4: 1, about 0.5: 1 , approximately 0.6: 1, approximately 0.7: 1, approximately 0.8: 1, approximately 0.9: 1, approximately 1: 1, approximately 1.2: 1, approximately 1.4: 1, approximately 1 , 6: 1, approximately 1.8: 1, approximately 2: 1, approximately 2.2: 1, approximately 2.4: 1, approximately 2.6: 1, approximately 2.8: 1, approximately 3: 1, about 3.2: 1, about 3.4: 1, about 3.6: 1, about 3.8: 1 or about 4: 1.
In embodiments, nicotine is protonated. In embodiments, the number or moles of organic acid functional groups are equal to or greater than the molar amount of nicotine. In embodiments, the number or moles of organic acid functional groups is equal to the molar amount of nicotine.
In embodiments, the number or moles of functional groups of organic acid are greater than the molar amount of nicotine.
In some embodiments, the number or moles of organic acid functional groups are from about 1.1 times higher to about 3.0 times higher than the molar amount of nicotine. In embodiments, the number of functional groups of organic acid is from about 1.5 times higher to about 2.2 times higher than the molar amount of nicotine.
In embodiments, the quantity or the number of moles of functional groups of excess organic acid is approximately 1.1 times greater, or approximately 1.2 times greater, or approximately 1.3 times greater, or approximately 1.4 times greater, or approximately 1.5 times greater, or approximately 1.6 times greater, or approximately 1.7 times greater, or approximately 1.8 times greater, or approximately 2 times greater, or approximately 2, 1 times greater, or approximately 2.2 times greater, or approximately 2.3 times greater, or approximately 2.4 times greater, or approximately 2.5 times greater, or approximately 2.6 times greater, or approximately 2.7 times greater, or approximately 2.8 times greater, or approximately 2.9 times greater, or approximately 3.0 times greater, etc., than the molar amount of nicotine present in the formulation. In embodiments, the excess amount or moles of functional groups of organic acid produce less harshness upon inhalation in a user compared to a control formulation.
In some embodiments, the molar ratio of organic acid to nicotine is about 0.5: 1. In embodiments, the molar ratio of organic acid to nicotine is about 0.6: 1. In embodiments, the molar ratio of organic acid to nicotine is about 0.7: 1. In embodiments, the molar ratio of organic acid to nicotine is about 0.8: 1. In embodiments, the molar ratio of organic acid to nicotine is about 0.9: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.0: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.1: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.2: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.3: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.4: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.5: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.6: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.7: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.8: 1. In embodiments, the molar ratio of organic acid to nicotine is about 1.9: 1. In embodiments, the molar ratio of organic acid to nicotine is about 2.0: 1. In embodiments, the molar ratio of organic acid to nicotine is about 3: 1. In embodiments, the molar ratio of organic acid to nicotine is about 4: 1. In embodiments, the molar ratio of organic acid to nicotine is about 5: 1. In embodiments, the molar ratio of organic acid to nicotine is about 6: 1. In embodiments, the molar ratio of organic acid to nicotine is about 7: 1. In embodiments, the molar ratio of organic acid to nicotine is about 8: 1. In embodiments, the molar ratio of organic acid to nicotine is about 9: 1. In embodiments, the molar ratio of organic acid to nicotine is about 10: 1. In embodiments, the molar ratio of organic acid to nicotine is about 11: 1. In embodiments, the molar ratio of organic acid to nicotine is about 12: 1. In embodiments, the molar ratio of organic acid to nicotine is about 13: 1. In embodiments, the molar ratio of organic acid to nicotine is about 14: 1. In embodiments, the molar ratio of organic acid to nicotine is about 15: 1. In embodiments, the molar ratio of organic acid to nicotine is about 16: 1. In embodiments, the molar ratio of organic acid to nicotine is about 17: 1. In embodiments, the molar ratio of organic acid to nicotine is about 18: 1. In embodiments, the molar ratio of organic acid to nicotine is about 19: 1. In embodiments, the molar ratio of organic acid to nicotine is about 20: 1.
In some embodiments, the molar ratio of organic acid to nicotine is at least 0.5: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 0.6: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 0.7: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 0.8: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 0.9: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.0: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.1: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.2: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.3: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.4: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.5: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.6: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.7: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.8: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 1.9: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 2.0: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 3: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 4: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 5: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 6: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 7: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 8: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 9: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 10: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 11: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 12: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 13: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 14: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 15: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 16: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 17: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 18: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 19: 1. In embodiments, the molar ratio of organic acid to nicotine is at least 20: 1.
Nicotine is an alkaloid molecule that has two basic nitrogen. It can occur in different protonation states. Nicotine is "protonated" if at least one of the two nitrogen atoms is covalently linked to a proton. Protonated nicotine includes protonated mononicotin, diprotonated nicotine, and combinations thereof. If a nitrogen is protonated, nicotine is a "monoprotonated" nicotine. If two nitrogen are protonated, then nicotine is a "diprotonated" nicotine. If no protonation is present, nicotine is called "free base" nicotine. In embodiments, when nicotine is combined with a sufficient amount of acid, the nicotine becomes protonated. Once protonated, the positively charged nicotine and the formulation may further comprise a counterion. In embodiments, the counterion is the conjugate base of the acid. For example, when the acid is benzoic acid, the counterion can be benzoate, thus forming a nicotine benzoate.
[0195] In embodiments, different liquid nicotine formulations produce different degrees of increase in a biological effect related to nicotine (for example, a faster rise in heart rate). In embodiments, different liquid nicotine formulations produce different degrees of satisfaction, stimulation, administration of nicotine, and / or increase in an individual's heart rate. In embodiments, the degree of protonation of nicotine affects satisfaction, stimulation, administration of nicotine, and / or heart rate so that more protonation is more satisfactory compared to less protonation. In embodiments, nicotine, for example in the formulation and / or aerosol, is monoprotonated. In embodiments, nicotine, for example in the formulation and / or aerosol, is diprotonated. In embodiments, nicotine, for example in the formulation and / or aerosol, is present in more than one protonation state, for example, a balance between monoprotonated and diprotonated nicotine. In embodiments, the degree of protonation of nicotine is dependent on the nicotine: acid ratio used in the formulation. In embodiments, the degree of protonation of nicotine is dependent on the solvent. In embodiments, the degree of protonation of nicotine has not been determined.
In embodiments, a liquid vehicle comprises a solvent or liquid medium in which a protonated nicotine is soluble (for example, under ambient conditions, such as 25 degrees Celsius) so that the protonated nicotine does not form a solid precipitate. Examples include, but are not limited to, glycerol, propylene glycol, trimethylene glycol, water, ethanol and the like, as well as combinations thereof. In embodiments, the liquid vehicle includes a ratio of propylene glycol and vegetable glycerin. In embodiments, the liquid vehicle comprises 10% to 70% propylene glycol and 90% to 30% vegetable glycerin. In embodiments, the liquid vehicle comprises 20% to 50% propylene glycol and 80% to 50% vegetable glycerin. In embodiments, the liquid vehicle comprises 30% propylene glycol and 70% vegetable glycerin. In embodiments, the liquid vehicle is completely propylene glycol or vegetable glycerin. In embodiments, the liquid vehicle comprises another aerosol agent similar to propylene glycol, glycerin, or other glycols or the like, or any combination thereof.
In embodiments, heating an amount of a liquid nicotine formulation produces an aerosol, at least about 50% acid in the amount being in the aerosol. In embodiments, at least about 90% of the nicotine in the amount being in the aerosol. In embodiments, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least 95% or at least about 99% of the acid in the quantity is in the aerosol. In embodiments, at least about 50% to about 99% of the acid in the amount is in the aerosol. In embodiments, at least about 50% to about 95% of the acid in the amount is in the aerosol. In embodiments, at least about 50% to about 90% of the acid in the amount is in the aerosol. In embodiments, at least about 50% to about 80% of the acid in the amount is in the aerosol. In embodiments, at least about 50% to about 70% of the acid in the amount is in the aerosol. In embodiments, at least about 50% to about 60% of the acid in the amount is in the aerosol. In embodiments, at least about 60% to about 99% of the acid in the amount is in the aerosol. In embodiments, at least about 60% to about 95% of the acid in the amount is in the aerosol. In embodiments, at least about 60% to about 90% of the acid in the amount is in the aerosol. In embodiments, at least about 60% to about 80% of the acid in the amount is in the aerosol. In embodiments, at least about 60% to about 70% of the acid in the amount is in the aerosol. In embodiments, at least about 70% to about 99% of the acid in the amount is in the aerosol. In embodiments, at least about 70% to about 95% of the acid in the amount is in the aerosol. In embodiments, at least about 70% to about 90% of the acid in the amount is in the aerosol. In embodiments, at least about 70% to about 80% of the acid in the amount is in the aerosol. In embodiments, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least 95% or at least about 99% of the nicotine in the quantity is in the aerosol. In embodiments, at least about 50% to about 99% of the nicotine in the amount is in the aerosol. In embodiments, at least about 50% to about 95% of the nicotine in the amount is in the aerosol. In embodiments, at least about 50% to about 90% of the nicotine in the amount is in the aerosol. In embodiments, at least about 50% to about 80% of the nicotine in the amount is in the aerosol. In embodiments, at least about 50% to about 70% of the nicotine in the amount is in the aerosol. In embodiments, at least about 50% to about 60% of the nicotine in the amount is in the aerosol. In embodiments, at least about 60% to about 99% of the nicotine in the amount is in the aerosol. In embodiments, at least about 60% to about 95% of the nicotine in the amount is in the aerosol. In embodiments, at least about 60% to about 90% of the nicotine in the amount is in the aerosol. In embodiments, at least about 60% to about 80% of the nicotine in the amount is in the aerosol. In embodiments, at least about 60% to about 70% of the nicotine in the amount is in the aerosol. In embodiments, at least about 70% to about 99% of the nicotine in the amount is in the aerosol. In embodiments, at least about 70% to about 95% of the nicotine in the amount is in the aerosol. In embodiments, at least about 70% to about 90% of the nicotine in the amount is in the aerosol. In embodiments, at least about 70% to about 80% of the nicotine in the amount is in the aerosol.
In embodiments, the aerosol is delivered in the form of particles small enough to be administered via the oral or nasal cavity and into the lungs of a user, for example the alveoli of the lungs. an user. In embodiments, the aerosol particles have dimensions (for example, have a diameter) of from about 0.1 micron to about 5 microns, from about 0.1 micron to about 4.5 microns, from about 0.1 microns to about 4 microns from about 0.1 microns to about 3.5 microns, from about 0.1 microns to about 3 microns from about 0.1 microns to about 2.5 microns, from about 0.1 micron to about 2 microns from about 0.1 micron to about 1.5 microns, from about 0.1 microns to about 1 micron, from about 0.1 microns to about 0.9 microns, d '' about 0.1 micron to about 0.8 micron from about 0.1 micron to about 0.7 micron, from about 0.1 micron to about 0.6 micron from about 0.1 micron to about 0, 5 micron, from about 0.1 micron to about 0.4 micron from about 0.1 micron to about 0.3 micron, from about 0.1 micron to about 0.2 micron from about 0.2 micron to about 5 micron, from about 0.2 micron to about 4.5 micron, from about 0.2 micron to e about 4 micron, from about 0.2 micron to about 3.5 micron, from about 0.2 micron to about 3 micron, from about 0.2 micron to about 2.5 micron, from about 0.2 micron to about 2 micron, from about 0.2 micron to about 1.5 micron, from about 0.2 micron to about 1 micron, from about 0.2 micron to about 0.9 micron, from about 0 0.2 micron to about 0.8 micron, from about 0.2 micron to about 0.7 micron from about 0.2 micron to about 0.6 micron, from about 0.2 micron to about 0.5 micron from about 0.2 micron to about 0.4 micron, from about 0.2 micron to about 0.3 micron from about 0.3 micron to about 5 microns, from about 0.3 micron to about 4, 5 microns from approximately 0.3 microns to approximately 4 microns, from approximately 0.3 microns to approximately 3.5 microns from approximately 0.3 microns to approximately 3 microns, from approximately 0.3 microns to approximately 2, 5 microns from about 0.3 microns to about 2 microns, from about 0.3 microns to about 1.5 microns, from about 0.3 microns to about 1 micron, about 0.3 micron to about 0.9 micron, about 0.3 micron to about 0.8 micron, about 0.3 micron to about 0.7 micron about 0, 3 micron to about 0.6 micron, from about 0.3 micron to about 0.5 micron from about 0.3 micron to about 0.4, from about 0.4 micron to about 5 microns, from about 0.4 micron to about 4.5 micron, from about 0.4 micron to about 4 micron from about 0.4 micron to about 3.5 micron, from about 0.4 micron to about 3 micron 0.4 micron to approximately 2.5 microns, approximately 0.4 micron to approximately 2 microns approximately 0.4 micron to approximately 1.5 microns, approximately 0.4 micron to approximately 1 microns, from about 0.4 micron to about 0.9 micron, from about 0.4 micron to about 0.8 micron from about 0.4 micron to about 0.7 micron, from about 0.4 micron to about 0, 6 micron from about 0.4 micron to about 0.5 micron, from about 0.5 micron to about 5 microns, from about 0.5 micron to about 4.5 microns, from about 0.5 microns to about 4 microns, from about 0.5 microns to about 3.5 microns, from about 0.5 microns to about 3 microns, from about 0.5 microns to about 2 , 5 microns, from about 0.5 microns to about 2 microns, from about 0.5 microns to about 1.5 microns, from about 0.5 microns to about 1 micron, from about 0.5 microns to approximately 0.9 micron, approximately 0.5 micron to approximately 0.8 micron, approximately 0.5 micron to approximately 0.7 micron, approximately 0.5 micron to approximately 0.6 micron, approximately 0.6 micron to approximately 5 microns, approximately 0.6 micron to approximately 4.5 microns, approximately 0.6 micron to approximately 4 microns, approximately 0.6 micron to approximately 3.5 microns, from approximately 0.6 microns to approximately 3 microns, from approximately 0.6 microns to approximately 2.5 microns, from approximately 0.6 microns to approximately 2 microns, from approximately 0.6 microns to approximately 1.5 micron, from about 0.6 micron to about 1 micron, from about 0.6 micron to about 0.9 micron, from about 0.6 micron to about on 0.8 micron, from about 0.6 micron to about 0.7 micron, from about 0.8 micron to about 5 microns, from about 0.8 micron to about 4.5 microns, from about 0 , .8 micron to about 4 microns, from about 0.8 microns to about 3.5 microns, from about 0.8 microns to about 3 microns, from about 0.8 microns to about 2.5 microns, from approximately 0.8 micron to approximately 2 microns, approximately 0.8 micron to approximately 1.5 microns, approximately 0.8 micron to approximately 1 micron, approximately 0.8 microns to approximately 0.9 microns, from about 0.9 microns to about 5 microns, from about 0.9 microns to about 4.5 microns, from about 0.9 microns to about 4 microns, from about 0.9 microns to about 3.5 microns, from about 0.9 microns to about 3 microns, from about 0.9 microns to about 2.5 microns, from about 0.9 microns to about 2 microns, from about 0.9 microns to about 1 .5 micron, from about 0.9 micron to about 1 micron, from about 1 micron to about 5 microns, from about 1 micron to approx. ron 4.5 microns, from about 1 micron to about 4 microns, from about 1 micron to about 3.5 microns, from about 1 micron to about 3 microns, from about 1 micron to about 2.5 microns, from about 1 micron to about 2 microns, from about 1 micron to about 1.5 microns.
In embodiments, an amount of liquid nicotine formulation supplied to the heater includes a volume or a mass. In embodiments, the amount is quantified "per puff". In embodiments, the amount includes a volume of about 1 µl, about 2 µΐ, about 3 µΐ, about 4 µΐ, about 5 µΐ, about 6 µΐ, about 7 µΐ, about 8 µΐ, about 9 µΐ, about 10 μΐ, approximately 15 μΐ, approximately 20 μΐ, approximately 25 μΐ, approximately 30 μΐ, approximately 35 μΐ, approximately 40 μΐ, approximately 45 μΐ, approximately 50 μΐ, approximately 60 μΐ, approximately 70 μΐ, approximately 80 μΐ, approximately 90 μΐ , approximately 100 μΐ, or more than approximately 100 μΐ. In embodiments, the amount includes a mass of about 1 mg, about 2 mg, about 3 mg, about 4 mg, about 5 mg, about 6 mg, about 7 mg, about 8 mg, about 9 mg, about 10 mg, approximately 15 mg, approximately 20 mg, approximately 25 mg, approximately 30 mg, approximately 35 mg, approximately 40 mg, approximately 45 mg, approximately 50 mg, approximately 60 mg, approximately 70 mg, approximately mg, approximately 90 mg, about 100 mg, or more than about 100 mg.
In embodiments, the nicotine in the aerosol from a device described above is delivered (for example, absorbed) faster than the nicotine in the smoke of a conventional cigarette, so that less nicotine is required in the aerosol. In embodiments, a puff of aerosol contains less nicotine than a puff of a conventional cigarette. In embodiments, the puff of aerosol is the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth or tenth puff from a device containing a cartridge presently described when the device is fully charged and a new cartridge is used. In embodiments, the puff of the conventional cigarette is the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth or tenth puff of the conventional cigarette after the cigarette is initially lit. In embodiments, a "puff" is a volume of about 40 ml, 45 ml, 50 ml, 55 ml, 60 ml, 65 ml, 70 ml, 75 ml or 80 ml of aerosol (in the case of '' a device presently described) or smoke (in the case of a conventional cigarette). In embodiments, the puff is sucked from the device or the conventional cigarette for a period of 1 to 5 seconds. In embodiments, the puff is sucked from the device or the conventional cigarette for a period of 2 to 3 seconds. In embodiments, the puff is sucked from the device or the conventional cigarette for a period of 2 to 3 seconds. In embodiments, the puff is sucked from the conventional device or cigarette for a period of approximately 1, 2, 3, 4 or 5 seconds. In embodiments, the puff is sucked from the device or the conventional cigarette for a period of about 1 second. In embodiments, the puff is sucked from the device or the conventional cigarette for a period of about 2 seconds. In embodiments, the puff is aspirated from the device or the conventional cigarette for a period of approximately 3 seconds. In embodiments, the puff is sucked from the device or the conventional cigarette for a period of about 4 seconds. In embodiments, the puff is sucked from the device or conventional cigarette for a period of about 5 seconds. In embodiments, less nicotine is contained in a puff of a device presently described compared to a conventional cigarette, the puff coming from the device having a volume of about 70 ml and being sucked from the device in a period of time. about 3 seconds, and the puff of the conventional cigarette having a volume of about 55 ml and being drawn from the conventional cigarette in a period of about 2 seconds. In embodiments, a puff of 40 to 80 ml (for example,
ΊΟ ml, 45 ml, 50 ml, 55 ml, 60 ml, 65 ml, 70 ml, 75 ml, or 80 ml) aspirated from a device presently described in a period of approximately 1 to 5 seconds (for example , approximately 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 2 to 5, 2 to 4, 2 to 3 or 1 to 3 seconds) contains approximately 0.5 1 mg of nicotine. In embodiments, the puff contains about 0.5, 0.55, 0.6, 0.65, 0.75, 0.80, 0.85, 0.95, or 1 mg of nicotine. In embodiments, the puff contains 0.5 to 0.75 mg of nicotine. In embodiments, the puff contains about 0.75 to 1 mg of nicotine. In embodiments, the puff contains 0.65 to 0.85 mg of nicotine.
In embodiments, more nicotine in the aerosol from a device described herein is administered (for example, absorbed) by a user compared to nicotine in the smoke of a conventional cigarette, so less nicotine is exhaled by the user. In this context, the "amount of nicotine exhaled" is the amount of nicotine that exits a user's respiratory tract when the user first exhales after inhaling a puff. In embodiments, the amount of nicotine exhaled by a user is lower when using a device presently described compared to the use of a conventional cigarette. In embodiments, the amount of nicotine exhaled when using a device as presently described is at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40 %, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80% or 95% lower compared to the use of a conventional cigarette. In embodiments, when a user inhales an aerosol produced by a device presently described, at least about 75, 80, 85, 90, 95, 96, 97, 98 or 99% of the nicotine remains in the user ( that is, has not expired). In embodiments, when a user inhales an aerosol produced by a device described herein, about 80 to 100%, 80 to 90%, 85 to 95%, 90 to 100%, 95 to 100%, 90 to 95% , 90 to 99%, 95 to 99% of the nicotine is not expired. In embodiments, when a user inhales an aerosol produced by a device described herein, no nicotine is expired. In embodiments, a device presently described is more effective in controlling the dose of nicotine per puff than a conventional cigarette.
In embodiments, a liquid nicotine formulation may include one or more flavoring agents.
In embodiments, the flavor of the constituent acid used in the formulation is taken into account in the choice of the acid. In embodiments, a suitable acid has minimal or no toxicity to humans at the concentrations used. In embodiments, a suitable acid is compatible with the components of the electronic nicotine delivery system with which it comes into contact or can come into contact at the concentrations used. That is, such an acid does not degrade or otherwise react with the components of the electronic nicotine delivery system with which it comes into contact or may come into contact. In embodiments, the smell of the constituent acid used to protonate nicotine is taken into account in the choice of a suitable acid. In embodiments, the concentration of protonated nicotine in the vehicle can affect user satisfaction. In embodiments, the flavor of the formulation is adjusted by changing the acid. In embodiments, the flavor of the formulation is adjusted by adding exogenous flavoring agents. In embodiments, an acid having an unpleasant taste or odor is used in minimal amounts to attenuate such characteristics. In embodiments, an acid having an exogenous pleasant taste or odor is added to the formulation. Nonlimiting examples of organic acids which can impart aerosol flavor and aroma at certain rates include acetic acid, oxalic acid, malic acid, isovaleric acid, lactic acid, citric acid, phenylacetic acid and myristic acid.
[0204] In embodiments, the amount of nicotine aerosol (for example, including protonated nicotine) inhaled can be determined by the user. In embodiments, the user can, for example, modify the amount of nicotine by adjusting the inhalation force.
[0205] In some embodiments, the electronic nicotine delivery system does not deliver an increased level of oxygen to the user, for example, relative to ambient oxygen levels. In some embodiments, the electronic nicotine delivery system does not include pressurized oxygen gas, or a chemical reserve of oxygen for inclusion in the aerosol. In embodiments, the aerosol comprises, consists essentially of, or consists of a liquid formulation of aerosolized nicotine, optionally in combination with ambient air.
Terminology When a characteristic or an element is currently referenced as being “on” another characteristic or another element, it may be directly on the other characteristic or element or characteristics and / or intermediate elements may also be present . On the other hand, when a characteristic or an element is referenced as being "directly on" another characteristic or another element, there are no characteristics or intermediate elements present. It should be understood that, when a characteristic or an element is referenced as being “connected”, “fixed” or “coupled” to another characteristic or another element, it can be directly linked, fixed or coupled to the other characteristic or element or else intermediate characteristics or elements may be present. On the other hand, when a characteristic or an element is referenced as being "directly connected", "directly fixed" or "directly coupled" to another characteristic or another element, there are no characteristics or intermediate elements present.
Although they are described or represented with reference to an embodiment, the characteristics and elements described or represented can be applied to other embodiments. It will be apparent to those skilled in the art that references to a structure or an element which is arranged "adjacent" to another element may include parts which overlap or are below the adjacent element.
The terminology currently used is intended to describe specific embodiments and implementations only and is not intended to be limiting. For example, in the present context, the singular forms "one", "one" and "the" are intended to also include the plural forms, unless clearly indicated in the context. It will further appear that the terms "includes" and / or "comprising", when used in this specification, specify the presence of characteristics, steps, operations, elements and / or components, but do not exclude the presence or adding one or more other elements, steps, operations, elements, components, and / or groups thereof. In this context, the term "and / or" includes any and all combinations of one or more of the associated listed items and may be abbreviated as "/".
In the above descriptions and in the claims, expressions such as "at least one of" or "one or more of" may be present followed by a joint list of elements or characteristics . The term "and / or" can also occur in a list of two or more of two characteristics or elements. Unless otherwise implicit or explicit to the contrary in the context in which it is used, such an expression is intended to denote any of the elements or characteristics individually listed or any of the elements or characteristics mentioned in combination with any of the other elements or characteristics mentioned. For example, the phrases "at least one of A and B"; "One or more of A and B"; and "A and / or B" are each intended to denote "A alone, B alone, or A and B jointly". A similar interpretation is also provided for lists comprising three or more elements. For example, the phrases "at least one of A, B and C"; "One or more of A, B and C"; and "A, B and / or C" are each intended to denote "A alone, B alone, C alone, A and B jointly, A and C jointly, B and C jointly, or A and B and C jointly". The use of the term "based on", above and in the claims is intended to refer to, "based, at least in part, on", so that a feature or element not mentioned is also authorized.
Spatially relative terms, such as "front", "rear", "under", "below", "lower", "on", "upper" and the like, can be used presently for ease of reference description to describe a relationship of an element or characteristic with other element (s) or characteristic (s) as illustrated in the figures. It will appear that the spatially relative terms are intended to cover different orientations of the device during use or operation, in addition to the orientation described in the figures. For example, if a device in the figures is inverted, the elements described as being "under" or "below" other elements or characteristics would then be oriented "on" the other elements or characteristics. Therefore, the exemplary term "under" can cover both an over and under orientation. The device can be oriented differently (rotated 90 degrees or in other orientations) and the spatially relative descriptors currently used interpreted accordingly. Similarly, the terms "up", "down", "vertical", "horizontal" and the like are presently used for explanatory purposes only, unless specifically stated otherwise.
[0211] Although the terms "first" and "second" can currently be used to describe different characteristics / elements (including steps), these characteristics / elements should not be limited by these terms, unless otherwise indicated in the context . These terms can be used to distinguish one characteristic / element from another characteristic / element. Therefore, a first characteristic / a first element described below can be called a second characteristic / element and, similarly, a second characteristic / element described below. below can be called the first characteristic / first element without departing from the lessons described here.
In the present context in the specification and the claims, including as used in the examples and unless specifically indicated otherwise, all the numbers can be considered as if they were preceded by the word "approximately" or "approximately", even if the term does not appear expressly. The term "approximately" or "approximately" can be used when describing an amplitude and / or position to indicate that the value and / or position described is within a reasonably predictable range of values and / or positions. For example, a numeric value can have a value that is +/- 0.1% of the specified value (or range of values), +/- 1% of the specified value (or range of values), +/- 2 % of the specified value (or range of values), +/- 5% of the specified value (or range of values), +/- 10% of the specified value (or range of values), etc. The numerical values presently described should also be understood to include approximately or approximately this value, unless otherwise indicated in the context. For example, if the value "10" is described, then "about 10" is also described. Any numerical range presently mentioned is intended to include all of the sub-ranges included therein. It is also understood that when a value is described which is "less than or equal to", the value, "greater than or equal to the value" and the possible ranges between the values are also described, as will appropriately appear in the skilled person. For example, if the value "X" is described, the value "less than or equal to X" as well as "greater than or equal to X" (for example, where X is a numeric value) is also described. It is also understood that, throughout the application, data is provided in several different formats, and that this data represents end points and starting points, and ranges for any combination of the data points . For example, if a particular data point "10" and a particular data point "15" are described, it is understood that greater, greater than or equal to, less, less than or equal to, and equal to 10 and 15 are considered as described, as well as between 10 and 15. It is also understood that each unit between two particular units is also described. For example, if 10 and 15 are described, then 11, 12, 13 and 14 are also described.
[0213] Although different illustrative embodiments are described above, any one of a plurality of modifications can be made to different embodiments without departing from the present teachings. For example, the order in which different described process steps are performed can often be changed in other embodiments, and in other alternative embodiments, one or more process steps can be skipped together. Features of different device and system embodiments may be included in some embodiments and not in others. Therefore, the description made above is presented primarily to illustrate, and should not be interpreted to limit, the scope of the claims.
One or more aspects or elements of the object described here can be produced in digital electronic circuits, integrated circuits, specially designed integrated circuits (ASIC) specially designed, computer hardware of programmable grid networks of field (FPGA), firmware, software, and / or combinations thereof. These different aspects or elements may include implementation in one or more computer programs which are executable and / or interpretable on a programmable system comprising at least one programmable processor, which may be of special or general use, coupled to receive data and instructions from, and for transmitting data and instructions to, a storage system, at least one input device and at least one output device. The programmable system or the computer system may include clients and servers. A client and a server are generally distant from each other and typically interact over a communications network. The client and server relationship is established by means of computer programs executed on the respective computers and having a client-server relationship with each other.
These computer programs, which can also be called programs, software, software applications, applications, components, or code, include machine instructions for a programmable processor, and can be implemented in high-level procedural language, an object oriented programming language, a functional programming language, a logical programming language, and / or in an assembler / machine language. In the present context, the term “machine-readable medium” designates any program product, apparatus and / or computer device, such as, for example, magnetic disks, optical disks, memory, and programmable logic devices ( PLD), used to provide machine instructions and / or data to a programmable processor, comprising a machine-readable medium which receives machine instructions in the form of a machine-readable signal. The term "machine readable signal" refers to any signal used to provide machine instructions and / or data to a programmable processor. The machine-readable medium can store such machine instructions in a non-transient manner, such as, for example, on a non-transient semiconductor memory or a magnetic hard disk or any equivalent storage medium. Machine readable media may alternatively or additionally store such machine instructions in a transient manner, such as, for example, in a processor cache or other random access memory associated with one or more processor cores physical.
The examples and illustrations presently included describe, by way of illustration and not by way of limitation, specific embodiments in which the object can be put into practice. As mentioned, other embodiments can be used and derived therefrom, so that structural and logical substitutions and modifications can be made without departing from the scope of this description. Such embodiments of the subject of the invention may be presently designated individually or collectively by the term "invention" solely for the sake of convenience, and without the intention of voluntarily limiting the scope of this request to an invention or an inventive concept. any single, if more than one is, in fact, described. Therefore, although specific embodiments have been illustrated and described herein, any arrangement calculated to perform the same function can be substituted for the specific embodiments described. This description is intended to cover any and all adaptations or variations of different embodiments. Combinations of the above embodiments, and of other embodiments not presently described specifically, will appear to a person skilled in the art on reading the description given above.

权利要求:
Claims (1)
[1" id="c-fr-0001]
claims [Claim 1] A cartridge for a vaporizer device, the cartridge comprising: a reservoir chamber defined by a reservoir barrier, the reservoir chamber being configured to contain a liquid vaporizable material;a vaporization chamber in fluid communication with the reservoir chamber and comprising a capillary element configured to suck the liquid vaporizable material from the reservoir chamber to the vaporization chamber to be vaporized by a heating element;an air flow passage which extends through the vaporization chamber;an air flow control element for controlling a tank pressure in the tank chamber. [Claim 2] The cartridge of claim 1, wherein the air flow control member includes a fluid passage extending between the reservoir chamber and the air flow passage. [Claim 3] The cartridge of claim 2, wherein a diameter of the fluid passage is dimensioned to allow a surface tension of the liquid vaporizable material to prevent the passage of the liquid vaporizable material through the fluid passage when the reservoir pressure is approximately the same as second pressure along the air flow passage. [Claim 4] The cartridge of claim 3, wherein the diameter is dimensioned to allow the surface tension of the liquid vaporizable material to be broken when the reservoir pressure is less than the second pressure along the air flow passage, thereby allowing a volume of air to pass through the air flow control element and enter the tank chamber. [Claim 5] The cartridge of claim 1, wherein the air flow control member comprises a check valve or a duckbill valve. [Claim 6] The cartridge of claim 2, wherein the air flow control member comprises a coating comprising a vent material extending over an opening of the fluid passage. [Claim 7] The cartridge of claim 6, wherein the coating comprises a polytetrafluoroethylene (PTFE) material.
[Claim 8] The cartridge of claim 1, wherein the air flow control element comprises one or more of a septum, a valve and a pump. [Claim 9] The cartridge of claim 1, wherein the air flow control member includes an air passage extending along at least one side of a wick housing containing the vaporization chamber, in which the ventilation passage extends between the reservoir chamber and the vaporization chamber. [Claim 10] The cartridge of claim 1, wherein the air flow control member includes an air passage extending through a wick housing containing the vaporization chamber, wherein the air passage extends between the tank chamber and the vaporization chamber. [Claim 11] The cartridge of claim 1, further comprising a pressure sensor configured to detect pressure along the air flow passage. [Claim 12] The cartridge of claim 1, further comprising a secondary passage configured to draw air through a portion of the cartridge, the secondary passage being configured to merge with the air flow passage downstream of the vaporization chamber . [Claim 13] The cartridge of claim 1, further comprising a pressure sensing passage which extends between an outlet of the cartridge and a pressure sensor, the pressure sensing passage being separate from the air flow passage. [Claim 14] The cartridge of claim 1, further comprising an inlet positioned along a first side of the cartridge and an outlet positioned along a second side of the cartridge, the air flow passage extending between the inlet and outlet, the inlet and outlet being positioned along the first side and the second side, respectively, so that the inlet and the outlet are open when the cartridge is inserted into a vaporizer body in a first position and are closed when the cartridge is inserted into the vaporizer body in a second position. [Claim 15] A cartridge according to claim 1, wherein the capillary element comprises a flat configuration comprising at least a pair of opposite sides which extend parallel to each other. [Claim 16] Method comprising the steps of: letting an air flow pass through a vaporization chamber of a
[Claim 17] [Claim 18] [Claim 19] [Claim 20] [Claim 21] vaporizer device, thereby combining the flow of air with an aerosol formed in the vaporization chamber, the aerosol being formed by vaporization of a liquid vaporizable material sucked in from a porous wick extending between the vaporization chamber and a reservoir chamber containing the liquid vaporizable material;
sucking liquid vaporizable material along the porous wick from the reservoir chamber to the vaporization chamber, thereby creating a first pressure in the reservoir chamber which is less than a second pressure in an area outside of the vapor chamber tank ;
breaking a surface tension of the liquid vaporizable material along an aeration passage extending between the reservoir chamber and the area outside the reservoir chamber, thereby allowing a volume of air to pass through the tank chamber from the ventilation passage; and increasing the first pressure in the tank chamber so that the first pressure is approximately equal to the second pressure.
The method of claim 16, further comprising the step of preventing, as a result of the first pressure being approximately equal to the second pressure, a passage of fluid along the aeration passage.
The method of claim 17, wherein prevention is controlled by a fluid tension of a vaporizable fluid.
The method of claim 18, wherein the vaporizable fluid comprises at least one of the liquid vaporizable material and air. The method of claim 17, wherein an air flow control member includes the ventilation passage extending through a wick housing which contains the vaporization chamber.
The method of claim 20, wherein the air flow control member includes a fluid passage extending between the reservoir chamber and an air flow passage.

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BE1026672A9|2021-04-06|HEATING ELEMENT

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FR3086845A1|2020-04-10|Heating element

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WO2018037245A1|2018-03-01|Device and system

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FR3064490A1|2018-10-05|PORTABLE DEVICE FOR VAPORIZING AT LEAST ONE ACTIVE COMPOSITION

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BE1026749B1|2020-06-04|Smoking device

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JP2022502016A|2022-01-11|Aerosol generation system that provides preferential evaporation of nicotine

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US20210321668A1|2021-10-21|Vaporizer mouthpiece

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US20200196679A1|2020-06-25|Electronic cigarette

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US20210169141A1|2021-06-10|Hexagonal Cartridge

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EP3692841A1|2020-08-12|Smoking substitute apparatus

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FR3064491A1|2018-10-05|PORTABLE DEVICE FOR INHALING AT LEAST ONE ACTIVE COMPOSITION

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Petrella2021|Electronic cigarettes, vaping-related lung injury and lung cancer: where do we stand?

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WO2020161293A1|2020-08-13|Smoking substitute device

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WO2020161289A1|2020-08-13|Smoking substitute device

同族专利:

---

公开号 | 公开日

---

WO2020023535A1|2020-01-30|

---

CA3107413A1|2020-01-30|

---

US20200022417A1|2020-01-23|

---

EP3826705A1|2021-06-02|

---

CN110754696A|2020-02-07|

---

US11241044B2|2022-02-08|

---

CN211794315U|2020-10-30|

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法律状态:
2020-06-11| PLFP| Fee payment|Year of fee payment: 2 |

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2021-06-11| PLFP| Fee payment|Year of fee payment: 3 |

优先权:

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申请号 | 申请日 | 专利标题

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US201862702320P| true| 2018-07-23|2018-07-23|

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US62/702,320|2018-07-23|

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